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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Muto, Taichiro Taki, Yuko Tsutsui, Hiroko Yoshimoto, Tomohiro Matsumoto, Makoto Sasaki, Yuki Futatsugi-yumikura, Shizue Nakanishi, Kenji Yasuda, Koubun Matsushita, Kazufumi Ishii, Ken J. Akira, Shizuo Kawagoe, Tatsukata |
| Description | Author Affiliation: Yasuda K ( Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan.); |
| Abstract | When animals are infected with helminthic parasites, resistant hosts show type II helper T immune responses to expel worms. Recently, natural helper (NH) cells or nuocytes, newly identified type II innate lymphoid cells, are shown to express ST2 (IL-33 receptor) and produce IL-5 and IL-13 when stimulated with IL-33. Here we show the relevant roles of endogenous IL-33 for Strongyloides venezuelensis infection-induced lung eosinophilic inflammation by using Il33(-/-) mice. Alveolar epithelial type II cells (ATII) express IL-33 in their nucleus. Infection with S. venezuelensis or intranasal administration of chitin increases in the number of ATII cells and the level of IL-33. S. venezuelensis infection induces pulmonary accumulation of NH cells, which, after being stimulated with IL-33, proliferate and produce IL-5 and IL-13. Furthermore, S. venezuelensis infected Rag2(-/-) mice increase the number of ATII cells, NH cells, and eosinophils and the expression of IL-33 in their lungs. Finally, IL-33-stimulated NH cells induce lung eosinophilic inflammation and might aid to expel infected worms in the lungs. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 9 |
| Volume Number | 109 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2012-02-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Interleukins Physiology Intestinal Diseases, Parasitic Complications Lymphocytes Immunology Pulmonary Eosinophilia Etiology Strongyloidiasis Animals Bronchoalveolar Lavage Fluid Cytology CD4-Positive T-Lymphocytes DNA-Binding Proteins Deficiency Genetics Interleukin-13 Biosynthesis Interleukin-33 Interleukin-5 Pathology Larva Drug Effects Metabolism Mice Mice, Inbred C57BL Mice, Knockout Nippostrongylus Growth & Development Pulmonary Alveoli Strongylida Infections Strongyloides Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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