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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zhou, Yonggang Tao, Wei Feng, Weijun Stunnenberg, Henk G. Grummt, Ingrid Ling, Te Zhu, Qiaoyun Xie, Wenbing |
| Description | Author Affiliation: Xie W ( The Education Ministry, Key Laboratory of Cell Proliferation and Differentiation, Peking University, Beijing 100871, China.); |
| Abstract | rRNA genes (rDNA) exist in two distinct epigenetic states, active promoters being unmethylated and marked by euchromatic histone modifications, whereas silent ones are methylated and exhibit heterochromatic features. Here we show that the nucleosome remodeling and deacetylation (NuRD) complex establishes a specific chromatin structure at rRNA genes that are poised for transcription activation. The promoter of poised rRNA genes is unmethylated, associated with components of the preinitiation complex, marked by bivalent histone modifications and covered by a nucleosome in the 'off' position, which is refractory to transcription initiation. Repression of rDNA transcription in growth-arrested and differentiated cells correlates with elevated association of NuRD and increased levels of poised rRNA genes. Reactivation of transcription requires resetting the promoter-bound nucleosome into the 'on' position by the DNA-dependent ATPase CSB (Cockayne syndrome protein B). The results uncover a unique mechanism by which ATP-dependent chromatin remodeling complexes with opposing activities establish a specific chromatin state and regulate transcription. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 21 |
| Volume Number | 109 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2012-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Chromatin Metabolism Genes, RRNA Genetics Histones Mi-2 Nucleosome Remodeling And Deacetylase Complex Nucleosomes Transcriptional Activation Physiology Adenosine Triphosphatases Animals Cell Differentiation DNA Helicases DNA Repair Enzymes DNA-Binding Proteins Epigenesis, Genetic Mice NIH 3T3 Cells RNA Polymerase I RNA, Ribosomal Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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