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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Maiz, Jaione Karakossian, Movses H. Pakaprot, Narawut Thompson, Richard F. Robleto, Karla Otis, Thomas S. |
| Description | Author Affiliation: Maiz J ( Department of Neurobiology, David Geffen School of Medicine and Integrative Center for Learning and Memory, University of California, Los Angeles, CA 90095, USA.); |
| Abstract | Climbing fiber input to the cerebellum is believed to serve as a teaching signal during associative, cerebellum-dependent forms of motor learning. However, it is not understood how this neural pathway coordinates changes in cerebellar circuitry during learning. Here, we use pharmacological manipulations to prolong the postcomplex spike pause, a component of the climbing fiber signal in Purkinje neurons, and show that these manipulations enhance the rate of learning in classical eyelid conditioning. Our findings elucidate an unappreciated aspect of the climbing fiber teaching signal, and are consistent with a model in which convergent postcomplex spike pauses drive learning-related plasticity in the deep cerebellar nucleus. They also suggest a physiological mechanism that could modulate motor learning rates. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 41 |
| Volume Number | 109 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2012-10-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Blinking Physiology Conditioning, Eyelid Nerve Fibers Purkinje Cells Analysis Of Variance Animals Benzimidazoles Pharmacology Drug Effects Calcium Channel Agonists Cardiovascular Agents Cerebellar Nuclei Cerebellum Cytology Electric Stimulation Excitatory Amino Acid Antagonists Excitatory Postsynaptic Potentials GABA Antagonists Mice Picrotoxin Pyrimidines Quinoxalines Rats, Sprague-Dawley Time Factors Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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