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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lee, Soojung Shin, Hee-sup Kim, Angela Latchoumane, Charles Cheong, Eunji Augustine, George J. Kim, Guk Bae |
| Description | Author Affiliation: Kim A ( Center for Cognition and Sociality, Institute for Basic Science, Yusung-gu, Daejeon 305-811, Korea.); |
| Abstract | Sleep spindles are rhythmic patterns of neuronal activity generated within the thalamocortical circuit. Although spindles have been hypothesized to protect sleep by reducing the influence of external stimuli, it remains to be confirmed experimentally whether there is a direct relationship between sleep spindles and the stability of sleep. We have addressed this issue by using in vivo photostimulation of the thalamic reticular nucleus of mice to generate spindle oscillations that are structurally and functionally similar to spontaneous sleep spindles. Such optogenetic generation of sleep spindles increased the duration of non-rapid eye movement (NREM) sleep. Furthermore, the density of sleep spindles was correlated with the amount of NREM sleep. These findings establish a causal relationship between sleep spindles and the stability of NREM sleep, strongly supporting a role for the thalamocortical circuit in sleep regulation. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 50 |
| Volume Number | 109 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2012-12-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Sleep Stages Physiology Animals Electroencephalography Electrophysiological Phenomena Intralaminar Thalamic Nuclei Mice Mice, Transgenic Neocortex Optogenetics Periodicity Photic Stimulation Rhodopsin Genetics Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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