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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kitano, Satsuki Imai, Kumiko Miyachi, Hitoshi Wagatsuma, Keisuke Ikuta, Koichi Hara, Takahiro Shimba, Akihiro Tani-ichi, Shizue |
| Description | Author Affiliation: Tani-ichi S ( Laboratory of Biological Protection, Department of Biological Responses and Reproductive Engineering Team, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan. staniich@virus.kyoto-u.ac.jp); |
| Abstract | Interleukin (IL)-7 is a cytokine essential for T lymphocyte development and homeostasis. However, little is known about the roles of IL-7 receptor -chain (IL-7R ) in late stages of T-cell development. To address this question, we established IL-7R -floxed mice and crossed them with CD4-Cre transgenic mice. Resultant IL-7R conditional knockout (IL-7RcKO) mice exhibited marked reduction in CD8 single positive (SP) T cells, regulatory T cells (Tregs), and natural killer T (NKT) cells in thymus. The proportion and proliferation of both mature CD4SP and CD8SP thymocytes were decreased without affecting Runx expression. In addition, expression of the glucocorticoid-induced TNF receptor was reduced in CD4SP and CD8SP thymocytes, and expression of CD5 was decreased in CD8SP thymocytes. IL-7RcKO mice also showed impaired Treg and NKT cell proliferation and inhibition of NKT cell maturation. Bcl-2 expression was reduced in CD4SP and CD8SP thymocytes but not in Tregs and NKT cells, and introduction of a Bcl-2 transgene rescued frequency and CD5 expression of CD8SP thymocytes. Furthermore, IL-7RcKO mice exhibited greatly increased numbers of B cells and, to a lesser extent, γδ T and dendritic cells in thymus. Overall, this study demonstrates that IL-7R differentially controls development and maturation of thymocyte subpopulations in late developmental stages and suggests that IL-7R expression on ß T cells suppresses development of other cell lineages in thymus. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 2 |
| Volume Number | 110 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2013-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Differentiation Immunology Interleukin-7 Receptor Alpha Subunit Metabolism Lymphocyte Subsets Physiology Thymocytes Cytology Animals Bromodeoxyuridine Core Binding Factor Alpha Subunits Flow Cytometry Genetics Mice Mice, Knockout Proto-Oncogene Proteins C-bcl-2 Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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