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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Nott, Alexi Veenvliet, Jesse V. Muchardt, Christian Smidt, Marten P. Pasterkamp, R. Jeroen Riccio, Antonella Schacke, Stephan Derijck, Alwin A. H. A. Sirko, Piotr Nitarska, Justyna |
| Description | Author Affiliation: Nott A ( Medical Research Council Laboratory for Molecular Cell Biology, University College London, London, WC1E 6BT, United Kingdom.); |
| Abstract | Dynamic epigenetic modifications play a key role in mediating the expression of genes required for neuronal development. We previously identified nitric oxide (NO) as a signaling molecule that mediates S-nitrosylation of histone deacetylase 2 (HDAC2) and epigenetic changes in neurons. Here, we show that HDAC2 nitrosylation regulates neuronal radial migration during cortical development. Bead-array analysis performed in the developing cortex revealed that brahma (Brm), a subunit of the ATP-dependent chromatin-remodeling complex BRG/brahma-associated factor, is one of the genes regulated by S-nitrosylation of HDAC2. In the cortex, expression of a mutant form of HDAC2 that cannot be nitrosylated dramatically inhibits Brm expression. Our study identifies NO and HDAC2 nitrosylation as part of a signaling pathway that regulates cortical development and the expression of Brm in neurons. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 8 |
| Volume Number | 110 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2013-02-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Movement Chromatin Assembly And Disassembly Histone Deacetylase 2 Metabolism Neurons Cytology Nitric Oxide Transcription Factors Animals Cell Separation Cerebral Cortex Electroporation Flow Cytometry Mice Pregnancy Signal Transduction Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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