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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wong, Debbie Morell, Matthew K. Hayden, Matthew J. Reynolds, Matthew Saintenac, Cyrille Wang, Shichen Chao, Shiaoman Talbert, Luther Forrest, Kerrie Tomar, Luxmi See, Deven Akhunova, Alina Da Silva, Marta Lopez Huang, Bevan Emma Bockelman, Harold Brown-guedira, Gina L. Akhunov, Eduard Stephen, Stuart Kong, Stephan Anderson, James A. Kiani, Seifollah Korzun, Viktor Carter, Arron Dubcovsky, Jorge Dreisigacker, Susanne Sorrells, Mark E. Bai, Guihua Pumphrey, Michael Morrell, Peter Laurent Cavanagh, Colin R. Baenziger, Stephen |
| Description | Author Affiliation: Cavanagh CR ( Commonwealth Scientific and Industrial Research Organization, Plant Industry and Food Futures National Research Flagship, Canberra, ACT 2601, Australia.); |
| Abstract | Domesticated crops experience strong human-mediated selection aimed at developing high-yielding varieties adapted to local conditions. To detect regions of the wheat genome subject to selection during improvement, we developed a high-throughput array to interrogate 9,000 gene-associated single-nucleotide polymorphisms (SNP) in a worldwide sample of 2,994 accessions of hexaploid wheat including landraces and modern cultivars. Using a SNP-based diversity map we characterized the impact of crop improvement on genomic and geographic patterns of genetic diversity. We found evidence of a small population bottleneck and extensive use of ancestral variation often traceable to founders of cultivars from diverse geographic regions. Analyzing genetic differentiation among populations and the extent of haplotype sharing, we identified allelic variants subjected to selection during improvement. Selective sweeps were found around genes involved in the regulation of flowering time and phenology. An introgression of a wild relative-derived gene conferring resistance to a fungal pathogen was detected by haplotype-based analysis. Comparing selective sweeps identified in different populations, we show that selection likely acts on distinct targets or multiple functionally equivalent alleles in different portions of the geographic range of wheat. The majority of the selected alleles were present at low frequency in local populations, suggesting either weak selection pressure or temporal variation in the targets of directional selection during breeding probably associated with changing agricultural practices or environmental conditions. The developed SNP chip and map of genetic variation provide a resource for advancing wheat breeding and supporting future population genomic and genome-wide association studies in wheat. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 20 |
| Volume Number | 110 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2013-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Ploidies Triticum Genetics Alleles Crops, Agricultural Gene Frequency Genes, Plant Genetic Variation Genome, Plant Genotype Haplotypes Oligonucleotide Array Sequence Analysis Polymorphism, Single Nucleotide Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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