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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lee, Jonghyeob Blauwkamp, Timothy A. Kim, Seung K. Gu, Guoqiang Sugiyama, Takuya Liu, Lucy Nusse, Roeland Mclean, Graeme W. Benitez, Cecil M. Ghodasara, Amar Wright, Christopher V. E. |
| Description | Author Affiliation: Sugiyama T ( Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305-5329, USA.); |
| Abstract | Developmental biology is challenged to reveal the function of numerous candidate genes implicated by recent genome-scale studies as regulators of organ development and diseases. Recapitulating organogenesis from purified progenitor cells that can be genetically manipulated would provide powerful opportunities to dissect such gene functions. Here we describe systems for reconstructing pancreas development, including islet ß-cell and -cell differentiation, from single fetal progenitor cells. A strict requirement for native genetic regulators of in vivo pancreas development, such as Ngn3, Arx, and Pax4, revealed the authenticity of differentiation programs in vitro. Efficient genetic screens permitted by this system revealed that Prdm16 is required for pancreatic islet development in vivo. Discovering the function of genes regulating pancreas development with our system should enrich strategies for regenerating islets for treating diabetes mellitus. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 31 |
| Volume Number | 110 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2013-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Differentiation Glucagon-Secreting Cells Metabolism Insulin-Secreting Cells Stem Cells Animals Basic Helix-Loop-Helix Transcription Factors Biosynthesis Genetics DNA-Binding Proteins Diabetes Mellitus Therapy Cytology Homeodomain Proteins Mice Mice, Transgenic Nerve Tissue Proteins Paired Box Transcription Factors Transcription Factors Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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