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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jones, Glenville Deluca, Hector F. Ochalek, Justin T. Kaufmann, Martin Zhu, Jinge G. |
| Description | Author Affiliation: Zhu JG ( Department of Biochemistry, University of Wisconsin, Madison, WI 53706.); |
| Abstract | Bioactivation of vitamin D consists of two sequential hydroxylation steps to produce 1 ,25-dihydroxyvitamin D3. It is clear that the second or 1 -hydroxylation step is carried out by a single enzyme, 25-hydroxyvitamin D 1 -hydroxylase CYP27B1. However, it is not certain what enzyme or enzymes are responsible for the initial 25-hydroxylation. An excellent case has been made for vitamin D 25-hydroxylase CYP2R1, but this hypothesis has not yet been tested. We have now produced Cyp2r1 (-/-) mice. These mice had greater than 50% reduction in serum 25-hydroxyvitamin D3. Curiously, the 1 ,25-dihydroxyvitamin D3 level in the serum remained unchanged. These mice presented no health issues. A double knockout of Cyp2r1 and Cyp27a1 maintained a similar circulating level of 25-hydroxyvitamin D3 and 1 ,25-dihydroxyvitamin D3. Our results support the idea that the CYP2R1 is the major enzyme responsible for 25-hydroxylation of vitamin D, but clearly a second, as-yet unknown, enzyme is another contributor to this important step in vitamin D activation. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 39 |
| Volume Number | 110 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2013-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cholestanetriol 26-Monooxygenase Metabolism Vitamin D Analogs & Derivatives Animals Calcium Blood Deficiency Genetics Chromatography, High Pressure Liquid Epiphyses Gene Expression Regulation, Enzymologic Genes, Reporter Genome Luciferases Mass Spectrometry Mice Mice, Inbred C57BL Mice, Knockout Phosphorus RNA, Messenger Radioimmunoassay Real-Time Polymerase Chain Reaction Biosynthesis Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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