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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Knoch, Tobias A. Dixon, Jesse R. Ren, Bing Zuin, Jessica Van Der Reijden, Michael I. J. A. Wendt, Kerstin S. Van De Werken, Harmen J. G. Grosveld, Frank G. Ye, Zhen Van De Corput, Mariëtte P. C. Kolovos, Petros Van Ijcken, Wilfred F. J. Brouwer, Rutger W. W. |
| Description | Author Affiliation: Zuin J ( Department of Cell Biology, Biophysical Genomics, Department of Cell Biology, Center for Biomics, Cancer Genomics Center, Erasmus Medical Center, 3015 GE, Rotterdam, The Netherlands.); |
| Abstract | Recent studies of genome-wide chromatin interactions have revealed that the human genome is partitioned into many self-associating topological domains. The boundary sequences between domains are enriched for binding sites of CTCC-binding factor (CTCF) and the cohesin complex, implicating these two factors in the establishment or maintenance of topological domains. To determine the role of cohesin and CTCF in higher-order chromatin architecture in human cells, we depleted the cohesin complex or CTCF and examined the consequences of loss of these factors on higher-order chromatin organization, as well as the transcriptome. We observed a general loss of local chromatin interactions upon disruption of cohesin, but the topological domains remain intact. However, we found that depletion of CTCF not only reduced intradomain interactions but also increased interdomain interactions. Furthermore, distinct groups of genes become misregulated upon depletion of cohesin and CTCF. Taken together, these observations suggest that CTCF and cohesin contribute differentially to chromatin organization and gene regulation. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 3 |
| Volume Number | 111 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2014-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Cycle Proteins Metabolism Chromatin Chemistry Chromosomal Proteins, Non-Histone Gene Expression Regulation Repressor Proteins Binding Sites Cell Line Cell Nucleus Gene Expression Profiling HEK293 Cells Homeodomain Proteins Mitosis Multigene Family Nuclear Proteins Phosphoproteins Protein Binding Protein Structure, Tertiary Transcriptome Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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