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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Spring, Bryan Q. Oliva, Esther Mai, Zhiming Palanisami, Akilan Zheng, Xiang Goldschmidt, Ruth Rizvi, Imran Abu-yousif, Adnan O. Sears, R. Bryan Erdem, S. Sibel Anbil, Sriram Mensah, Lawrence B. Hasan, Tayyaba |
| Description | Author Affiliation: Spring BQ ( Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.); |
| Abstract | Drug-resistant micrometastases that escape standard therapies often go undetected until the emergence of lethal recurrent disease. Here, we show that it is possible to treat microscopic tumors selectively using an activatable immunoconjugate. The immunoconjugate is composed of self-quenching, near-infrared chromophores loaded onto a cancer cell-targeting antibody. Chromophore phototoxicity and fluorescence are activated by lysosomal proteolysis, and light, after cancer cell internalization, enabling tumor-confined photocytotoxicity and resolution of individual micrometastases. This unique approach not only introduces a therapeutic strategy to help destroy residual drug-resistant cells but also provides a sensitive imaging method to monitor micrometastatic disease in common sites of recurrence. Using fluorescence microendoscopy to monitor immunoconjugate activation and micrometastatic disease, we demonstrate these concepts of 'tumor-targeted, activatable photoimmunotherapy' in a mouse model of peritoneal carcinomatosis. By introducing targeted activation to enhance tumor selectively in complex anatomical sites, this study offers prospects for catching early recurrent micrometastases and for treating occult disease. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 10 |
| Volume Number | 111 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2014-03-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Drug Delivery Systems Immunoconjugates Therapeutic Use Monitoring, Immunologic Neoplasm Micrometastasis Diagnosis Drug Therapy Ovarian Neoplasms Pathology Animals Antibodies, Monoclonal Endoscopy Fluorescence Immunotherapy Mice Immunology Phototherapy Sensitivity And Specificity Research Support, N.I.H., Extramural Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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