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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mathis, Diane Morton, Angela M. Sefik, Esen Upadhyay, Rabi Benoist, Christophe Weissleder, Ralph |
| Description | Author Affiliation: Morton AM ( Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115.); |
| Abstract | Given mounting evidence of the importance of gut-microbiota/immune-cell interactions in immune homeostasis and responsiveness, surprisingly little is known about leukocyte movements to, and especially from, the gut. We address this topic in a minimally perturbant manner using Kaede transgenic mice, which universally express a photoconvertible fluorescent reporter. Transcutaneous exposure of the cervical lymph nodes to violet light permitted punctual tagging of immune cells specifically therein, and subsequent monitoring of their immigration to the intestine; endoscopic flashing of the descending colon allowed specific labeling of intestinal leukocytes and tracking of their emigration. Our data reveal an unexpectedly broad movement of leukocyte subsets to and from the gut at steady state, encompassing all lymphoid and myeloid populations examined. Nonetheless, different subsets showed different trafficking proclivities (e.g., regulatory T cells were more restrained than conventional T cells in their exodus from the cervical lymph nodes). The novel endoscopic approach enabled us to evidence gut-derived Th17 cells in the spleens of K/BxN mice at the onset of their genetically determined arthritis, thereby furnishing a critical mechanistic link between the intestinal microbiota, namely segmented filamentous bacteria, and an extraintestinal autoinflammatory disease. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 18 |
| Volume Number | 111 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2014-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Digestive System Immunology Microbiology Leukocytes Physiology Microbiota Adaptive Immunity Animals Antigens, CD45 Metabolism Arthritis, Experimental Pathology Cell Movement Cytology Genes, Reporter Immunity, Innate Luminescent Proteins Genetics Mice Mice, Inbred C57BL Mice, Inbred NOD Mice, Transgenic Photochemical Processes Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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