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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Akay, Turgay Tourtellotte, Warren G. Jessell, Thomas M. Arber, Silvia |
| Description | Author Affiliation: Akay T ( Howard Hughes Medical Institute and Departments of Neuroscience, Biochemistry and Molecular Biophysics, Kavli Institute of Brain Science, Columbia University, New York, NY 10032); Tourtellotte WG ( Department of Pathology and Neurology, Northwestern University, Chicago, IL 60611); Arber S ( Biozentrum, Department of Cell Biology, University of Basel, 4056 Basel, Switzerland); Jessell TM ( Howard Hughes Medical Institute and Departments of Neuroscience, Biochemistry and Molecular Biophysics, Kavli Institute of Brain Science, Columbia University, New York, NY 10032); |
| Abstract | Mammalian locomotor programs are thought to be directed by the actions of spinal interneuron circuits collectively referred to as 'central pattern generators.' The contribution of proprioceptive sensory feedback to the coordination of locomotor activity remains less clear. We have analyzed changes in mouse locomotor pattern under conditions in which proprioceptive feedback is attenuated genetically and biomechanically. We find that locomotor pattern degrades upon elimination of proprioceptive feedback from muscle spindles and Golgi tendon organs. The degradation of locomotor pattern is manifest as the loss of interjoint coordination and alternation of flexor and extensor muscles. Group Ia/II sensory feedback from muscle spindles has a predominant influence in patterning the activity of flexor muscles, whereas the redundant activities of group Ia/II and group Ib afferents appear to determine the pattern of extensor muscle firing. These findings establish a role for proprioceptive feedback in the control of fundamental aspects of mammalian locomotor behavior. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 47 |
| Volume Number | 111 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2014-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Locomotion Proprioception Animals Biomechanical Phenomena Mice Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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