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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Dasgupta, Maupali Stark, George R. Willard, Belinda Dermawan, Josephine Kam Tai |
| Description | Author Affiliation: Dasgupta M ( Department of Molecular Genetics and.); Dermawan JK ( Department of Molecular Genetics and starkg@ccf.org.); Willard B ( Proteomics Core, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.); Stark GR ( Department of Molecular Genetics and starkg@ccf.org.); |
| Abstract | Several transcription factors, including p53, NF-κB, and STAT3, are modified by the same enzymes that also modify histones, with important functional consequences. We have identified a previously unrecognized dimethylation of K49 of STAT3 that is crucial for the expression of many IL-6-dependent genes, catalyzed by the histone-modifying enzyme enhancer of zeste homolog 2 (EZH2). Loss of EZH2 is protumorigenic in leukemias, but its overexpression is protumorigenic in solid cancers. Connecting EZH2 to a functionally important methylation of STAT3, which is constitutively activated in many tumors, may help reveal the basis of the opposing roles of EZH2 in liquid and solid tumors and also may identify novel therapeutic opportunities. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 13 |
| Volume Number | 112 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2015-04-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Gene Expression Regulation, Neoplastic Polycomb Repressive Complex 2 Metabolism STAT3 Transcription Factor Cell Line, Tumor DNA Methylation Gene Expression Histone-Lysine N-Methyltransferase Histones Interleukin-6 Lysine Chemistry Mutation Neoplasms Phosphorylation Promoter Regions, Genetic Protein Processing, Post-Translational Retroviridae Transcription, Genetic Research Support, N.I.H., Extramural Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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