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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Döderlein, Gabriele Niehrs, Christof Anvarian, Zeinab Huang, Ya-lin Acebron, Sergio P. |
| Description | Author Affiliation: Huang YL ( Division of Molecular Embryology, German Cancer Research Center-Zentrum für Molekulare Biologie der Universität Heidelberg (DKFZ-ZMBH) Alliance, D-69120 Heidelberg, Germany); Anvarian Z ( Division of Molecular Embryology, German Cancer Research Center-Zentrum für Molekulare Biologie der Universität Heidelberg (DKFZ-ZMBH) Alliance, D-69120 Heidelberg, Germany); Döderlein G ( Division of Molecular Embryology, German Cancer Research Center-Zentrum für Molekulare Biologie der Universität Heidelberg (DKFZ-ZMBH) Alliance, D-69120 Heidelberg, Germany); Acebron SP ( Division of Molecular Embryology, German Cancer Research Center-Zentrum für Molekulare Biologie der Universität Heidelberg (DKFZ-ZMBH) Alliance, D-69120 Heidelberg, Germany); Niehrs C ( Division of Molecular Embryology, German Cancer Research Center-Zentrum für Molekulare Biologie der Universität Heidelberg (DKFZ-ZMBH) Alliance, D-69120 Heidelberg, Germany); |
| Abstract | During Xenopus development, Wnt signaling is thought to function first after midblastula transition to regulate axial patterning via ß-catenin-mediated transcription. Here, we report that Wnt/glycogen synthase kinase 3 (GSK3) signaling functions posttranscriptionally already in mature oocytes via Wnt/stabilization of proteins (STOP) signaling. Wnt signaling is induced in oocytes after their entry into meiotic metaphase II and declines again upon exit into interphase. Wnt signaling inhibits Gsk3 and thereby protects proteins from polyubiquitination and degradation in mature oocytes. In a protein array screen, we identify a cluster of mitotic effector proteins that are polyubiquitinated in a Gsk3-dependent manner in Xenopus. Consequently inhibition of maternal Wnt/STOP signaling, but not ß-catenin signaling, leads to early cleavage arrest after fertilization. The results support a novel role for Wnt signaling in cell cycle progression independent of ß-catenin. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 18 |
| Volume Number | 112 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2015-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Gene Expression Regulation, Developmental Glycogen Synthase Kinase 3 Metabolism Wnt1 Protein Xenopus Proteins Xenopus Laevis Embryology Animals Cell Cycle Fertilization Mitosis Oocytes Cytology Protein Array Analysis Signal Transduction Transcription, Genetic Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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