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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | D'souza, Rinaldo David Vijayaraghavan, Sukumar Parsa, Pirooz Victor |
| Description | Author Affiliation: Parsa PV ( Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO 80045 Neuroscience Program, University of Colorado School of Medicine, Aurora, CO 80045.); D'Souza RD ( Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO 80045 Neuroscience Program, University of Colorado School of Medicine, Aurora, CO 80045.); Vijayaraghavan S ( Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO 80045 Neuroscience Program, University of Colorado School of Medicine, Aurora, CO 80045 sukumar.v@ucdenver.edu.); |
| Abstract | In the mouse olfactory bulb glomerulus, the GABAergic periglomerular (PG) cells provide a major inhibitory drive within the microcircuit. Here we examine GABAergic synapses between these interneurons. At these synapses, GABA is depolarizing and exerts a bimodal control on excitability. In quiescent cells, activation of GABAA receptors can induce the cells to fire, thereby providing a means for amplification of GABA release in the glomerular microcircuit via GABA-induced GABA release. In contrast, GABA is inhibitory in neurons that are induced to fire tonically. PG-PG interactions are modulated by nicotinic acetylcholine receptors (nAChRs), and our data suggest that changes in intracellular calcium concentrations triggered by nAChR activation can be amplified by GABA release. Our results suggest that bidirectional control of inhibition in PG neurons can allow for modulatory inputs, like the cholinergic inputs from the basal forebrain, to determine threshold set points for filtering out weak olfactory inputs in the glomerular layer of the olfactory bulb via the activation of nAChRs. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 30 |
| Volume Number | 112 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2015-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Interneurons Physiology Olfactory Bulb Signal Transduction Gamma-Aminobutyric Acid Acetylcholine Action Potentials Animals Behavior, Animal Calcium Chemistry Mice Mice, Transgenic Models, Neurological Neural Inhibition Neurons Patch-Clamp Techniques Receptors, Cholinergic Receptors, Nicotinic Synapses Research Support, N.I.H., Extramural Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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