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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Irish, Joel D. Reuther, Joshua D. Potter, Ben A. Watkins, W. Scott Raff, Jennifer Powers, Michael Warner, Derek O'rourke, Dennis H. Tackney, Justin C. |
| Spatial Coverage | Alaska |
| Description | Author Affiliation: Tackney JC ( Department of Anthropology, University of Utah, Salt Lake City, UT 84112); Potter BA ( Department of Anthropology, University of Alaska, Fairbanks, AK 99775); Raff J ( Department of Anthropology, University of Kansas, Lawrence, KS 66045); Powers M ( DNA Sequencing Core, University of Utah, Salt Lake City, UT 84112); Watkins WS ( Department of Human Genetics, University of Utah, Salt Lake City, UT 84112); Warner D ( DNA Sequencing Core, University of Utah, Salt Lake City, UT 84112); Reuther JD ( Department of Anthropology, University of Alaska, Fairbanks, AK 99775); Irish JD ( Research Centre in Evolutionary Anthropology and Paleoecology, Liverpool John Moores University, Liverpool L33AF, United Kingdom.); O'Rourke DH ( Department of Anthropology, University of Utah, Salt Lake City, UT 84112); |
| Abstract | Pleistocene residential sites with multiple contemporaneous human burials are extremely rare in the Americas. We report mitochondrial genomic variation in the first multiple mitochondrial genomes from a single prehistoric population: two infant burials (USR1 and USR2) from a common interment at the Upward Sun River Site in central Alaska dating to ∼11,500 cal B.P. Using a targeted capture method and next-generation sequencing, we determined that the USR1 infant possessed variants that define mitochondrial lineage C1b, whereas the USR2 genome falls at the root of lineage B2, allowing us to refine younger coalescence age estimates for these two clades. C1b and B2 are rare to absent in modern populations of northern North America. Documentation of these lineages at this location in the Late Pleistocene provides evidence for the extent of mitochondrial diversity in early Beringian populations, which supports the expectations of the Beringian Standstill Model. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 45 |
| Volume Number | 112 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2015-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | DNA, Mitochondrial Genetics Genetic Variation Haplotypes Human Migration Models, Theoretical Phylogeny Alaska Archaeology Bayes Theorem Burial Evolution, Molecular Geography High-Throughput Nucleotide Sequencing History, Ancient Infant Likelihood Functions Models, Genetic Molecular Sequence Data Oligonucleotides Historical Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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