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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Haj-dahmane, Samir Bergeron, Richard Assadzada, Saleha Geddes, Sean D. Sokolovski, Alexandra Béïque, Jean-claude Lemelin, David |
| Description | Author Affiliation: Geddes SD ( uOttawa, Brain and Mind Research Institute Centre for Neural Dynamics, Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada K1H 8M5); Assadzada S ( uOttawa, Brain and Mind Research Institute Centre for Neural Dynamics, Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada K1H 8M5); Lemelin D ( uOttawa, Brain and Mind Research Institute Centre for Neural Dynamics, Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada K1H 8M5); Sokolovski A ( Ottawa Hospital Research Institute, Ottawa, ON, Canada K1Y 4E9); Bergeron R ( Ottawa Hospital Research Institute, Ottawa, ON, Canada K1Y 4E9); Haj-Dahmane S ( Research Institute on Addictions, University at Buffalo, Buffalo, NY 14203); Béïque JC ( uOttawa, Brain and Mind Research Institute Centre for Neural Dynamics, Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada K1H 8M5); |
| Abstract | Serotonin (5-HT) neurons located in the raphe nuclei modulate a wide range of behaviors by means of an expansive innervation pattern. In turn, the raphe receives a vast array of synaptic inputs, and a remaining challenge lies in understanding how these individual inputs are organized, processed, and modulated in this nucleus to contribute ultimately to the core coding features of 5-HT neurons. The details of the long-range, top-down control exerted by the medial prefrontal cortex (mPFC) in the dorsal raphe nucleus (DRN) are of particular interest, in part, because of its purported role in stress processing and mood regulation. Here, we found that the mPFC provides a direct monosynaptic, glutamatergic drive to both DRN 5-HT and GABA neurons and that this architecture was conducive to a robust feed-forward inhibition. Remarkably, activation of cannabinoid (CB) receptors differentially modulated the mPFC inputs onto these cell types in the DRN, in effect regulating the synaptic excitatory/inhibitory balance governing the excitability of 5-HT neurons. Thus, the CB system dynamically reconfigures the processing features of the DRN, a mood-related circuit believed to provide a concerted and distributed regulation of the excitability of large ensembles of brain networks. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 19 |
| Volume Number | 113 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2016-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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