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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wang, Junzhi Sun, Yao Walter, Thomas S. Wang, Xiangxi Zhu, Ling Hu, Zhongyu Rao, Zihe Dang, Minghao Ren, Jingshan Stuart, David I. Zhang, Bo Yuan, Shuai Gao, Qiang Kotecha, Abhay Fry, Elizabeth E. |
| Description | Author Affiliation: Wang X ( National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing 100101, China); Zhu L ( Division of Structural Biology, University of Oxford, Oxford OX3 7BN, United Kingdom.); Dang M ( National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing 100101, China.); Hu Z ( National Institutes for Food and Drug Control, Beijing 100050, China.); Gao Q ( National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing 100101, China.); Yuan S ( Sinovac Biotech Co., Ltd., Beijing 100085, China.); Sun Y ( National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing 100101, China.); Zhang B ( National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing 100101, China.); Ren J ( Sinovac Biotech Co., Ltd., Beijing 100085, China.); Kotecha A ( Division of Structural Biology, University of Oxford, Oxford OX3 7BN, United Kingdom.); Walter TS ( Division of Structural Biology, University of Oxford, Oxford OX3 7BN, United Kingdom.); Wang J ( Division of Structural Biology, University of Oxford, Oxford OX3 7BN, United Kingdom.); Fry EE ( National Institutes for Food and Drug Control, Beijing 100050, China.); Stuart DI ( Division of Structural Biology, University of Oxford, Oxford OX3 7BN, United Kingdom); Rao Z ( Division of Structural Biology, University of Oxford, Oxford OX3 7BN, United Kingdom); |
| Abstract | Hepatitis A virus (HAV) infects ∼1.4 million people annually and, although there is a vaccine, there are no licensed therapeutic drugs. HAV is unusually stable (making disinfection problematic) and little is known of how it enters cells and releases its RNA. Here we report a potent HAV-specific monoclonal antibody, R10, which neutralizes HAV infection by blocking attachment to the host cell. High-resolution cryo-EM structures of HAV full and empty particles and of the complex of HAV with R10 Fab reveal the atomic details of antibody binding and point to a receptor recognition site at the pentamer interface. These results, together with our observation that the R10 Fab destabilizes the capsid, suggest the use of a receptor mimic mechanism to neutralize virus infection, providing new opportunities for therapeutic intervention. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 4 |
| Volume Number | 114 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2017-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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