NDLI: Catalytic DNA (deoxyribozymes) for synthetic applications

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Silverman, Scott K.
Description	Author Affiliation: Silverman SK ( Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA. scott@scs.uiuc.edu);
Abstract	The discovery of naturally occurring catalytic RNA (RNA enzymes, or ribozymes) in the 1980s immediately revised the view of RNA as a passive messenger that solely carries information from DNA to proteins . Because DNA and RNA differ only by the absence or presence of a 2′-hydroxyl group on each ribose ring of the polymer , the question of ‘catalytic DNA?’ arises. Although no natural DNA catalysts have been reported, since 1994 many artificial DNA enzymes, or ‘deoxyribozymes’, have been described. Deoxyribozymes offer insight into the mechanisms of natural and artificial ribozymes. DNA enzymes are also used as tools for in vitro and in vivo biochemistry, and they are key components of analytical sensors. This review focuses primarily on catalytic DNA for synthetic applications. Broadly defined, deoxyribozymes may have the greatest potential for catalyzing reactions in which the high selectivities of ‘enzymes’ are advantageous relative to traditional small-molecule catalysts . Although the scope of DNA-catalyzed synthesis is currently limited in most cases to oligonucleotide substrates, recent efforts have began to expand this frontier in promising new directions.
ISSN	13597345
Journal	Chemical Communications
Issue Number	30
e-ISSN	1364548X
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2008-07-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	DNA, Catalytic Chemistry Metabolism Base Sequence Genetics Hydroxyl Radical Oligonucleotides RNA Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review
Content Type	Text
Resource Type	Article
Subject	Ceramics and Composites Chemistry Surfaces, Coatings and Films Materials Chemistry Metals and Alloys Electronic, Optical and Magnetic Materials Catalysis

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