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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kwon, Ick Chan Yhee, Ji Young Ahn, Dae-ro Kim, Kyoung-ran Kim, Byeong-su Kim, Da-rae Lee, Taemin |
| Description | Author Affiliation: Kim KR ( Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea.); |
| Abstract | A DNA tetrahedron is employed for efficient delivery of doxorubicin into drug -resistant breast cancer cells. The drug delivered with the DNA nanoconstruct is considerably cytotoxic, whereas free doxorubicin is virtually non-cytotoxic for the drug -resistant cells. Thus, the DNA tetrahedron, made of the inherently natural and biocompatible material, can be a good candidate for the drug carrier to overcome MDR in cancer cells. |
| ISSN | 13597345 |
| Journal | Chemical Communications |
| Issue Number | 20 |
| Volume Number | 49 |
| e-ISSN | 1364548X |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Publisher Date | 2013-02-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Subscribed |
| Subject Keyword | DNA Chemistry Doxorubicin Drug Carriers Breast Neoplasms Metabolism Pathology Carbocyanines Cell Survival Drug Effects Toxicity Drug Resistance, Neoplasm Female Humans MCF-7 Cells Nanostructures Journal Article Research Support, Non-U.S. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ceramics and Composites Chemistry Surfaces, Coatings and Films Materials Chemistry Metals and Alloys Electronic, Optical and Magnetic Materials Catalysis |
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