NDLI: Giant hollow $M_{n}L_{2n}$ spherical complexes: structure, functionalisation and applications

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Harris, Kate Fujita, Daishi Fujita, Makoto
Description	Author Affiliation: Harris K ( Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Tokyo 113-8656, Japan.);
Abstract	Drawing inspiration from the self-assembly of hollow spherical virus capsids and protein cages found in nature, a family of roughly spherical coordination polyhedra with general formula $M_{n}L_{2n}$ was designed and several members of the series have been synthesised. These spherical complexes are self-assembled upon reaction of bent bis(pyridine) ligands with $Pd^{2+}$ ions. The introduction of functional side chains into the ligands is straightforward, making the synthesis of both exo- and endohedrally functionalised spherical complexes possible. Accumulation of a high density of functional groups at the periphery of the spherical framework results in an enhancement of the weak interactions used in biomolecular recognition processes and the strong and selective interaction of the complex with a variety of substrates. Discrete and well-defined environments are generated within the spherical framework by functionalisation of the interior of the complex. These environments can be used for the selective encapsulation of guest molecules, including species as diverse as simple metal ions, fluoroalkanes and fullerenes . The well-defined cavity of the spherical complexes can also be exploited for the synthesis of precisely size-controlled nanoparticles and polymers . Most recently, a protein was successfully enclosed within a hollow self-assembled spherical complex, with a long-term view towards the control of protein functions for the development of new applications.
ISSN	13597345
Volume Number	49
Journal	Chemical Communications
Issue Number	60
e-ISSN	1364548X
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2013-07-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Coordination Complexes Chemistry Palladium Pyridines Ions Ligands Models, Molecular Ubiquitin Administration & Dosage Journal Article
Content Type	Text
Resource Type	Article
Subject	Ceramics and Composites Chemistry Surfaces, Coatings and Films Materials Chemistry Metals and Alloys Electronic, Optical and Magnetic Materials Catalysis

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