NDLI: Switchable supramolecular catalysis using DNA-templated scaffolds

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Aleman Garcia, Miguel Angel Hu, Yuwei Willner, Itamar
Description	Author Affiliation: Aleman Garcia MA ( Institute of Chemistry, The Minerva Center for Biohybrid Complex Systems, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. willnea@vms.huji.ac.il.); Hu Y ( Institute of Chemistry, The Minerva Center for Biohybrid Complex Systems, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. willnea@vms.huji.ac.il.); Willner I ( Institute of Chemistry, The Minerva Center for Biohybrid Complex Systems, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. willnea@vms.huji.ac.il.);
Abstract	Switchable β-cyclodextrin (β-CD)-induced hydrolysis of m-tert-butylphenyl acetate is demonstrated in the presence of supramolecular β-CD/adamantane oligonucleotide scaffolds. In one system, a duplex between a β-CD-functionalized nucleic acid and an adamantane-nucleic acid leads to a switchable catalytic system. In a second system, a β-CD/adamantane duplex is cooperatively generated by $K^{+}-stabilized$ G-quadruplex units. The binding of hemin to the second system yields a bifunctional DNA scaffold with alternate catalytic functions.
ISSN	13597345
Journal	Chemical Communications
Issue Number	10
Volume Number	52
e-ISSN	1364548X
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2016-01-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Adamantane Chemistry DNA, Catalytic Hemin Nanostructures Oligonucleotides Phenylacetates Beta-Cyclodextrins Metabolism G-Quadruplexes Hydrolysis Journal Article Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Ceramics and Composites Chemistry Surfaces, Coatings and Films Materials Chemistry Metals and Alloys Electronic, Optical and Magnetic Materials Catalysis

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