NDLI: Distinguishing N-acetylneuraminic acid linkage isomers on glycopeptides by ion mobility-mass spectrometry

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pagel, K. Seeberger, P. H. Kolarich, D. Hinneburg, H. Hofmann, J. Struwe, W. B. Altmann, F. Thader, A. Varón Silva, D.
Description	Author Affiliation: Hinneburg H ( Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14424 Potsdam, Germany. daniel.kolarich@mpikg.mpg.de and Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany. kevin.pagel@fu-berlin.de.); Hofmann J ( Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany. kevin.pagel@fu-berlin.de and Fritz Haber Institute of the Max Planck Society, 14195 Berlin, Germany.); Struwe WB ( Department of Chemistry, Physical and Theoretical Chemistry Laboratory, University of Oxford, OX1 3QZ, Oxford, UK.); Thader A ( Department of Chemistry, University of Natural Resources and Applied Life Sciences, Vienna, Austria.); Altmann F ( Department of Chemistry, University of Natural Resources and Applied Life Sciences, Vienna, Austria.); Varón Silva D ( Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14424 Potsdam, Germany. daniel.kolarich@mpikg.mpg.de.); Seeberger PH ( Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14424 Potsdam, Germany. daniel.kolarich@mpikg.mpg.de and Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany. kevin.pagel@fu-berlin.de.); Pagel K ( Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany. kevin.pagel@fu-berlin.de and Fritz Haber Institute of the Max Planck Society, 14195 Berlin, Germany.); Kolarich D ( Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14424 Potsdam, Germany. daniel.kolarich@mpikg.mpg.de.);
Abstract	Differentiating the structure of isobaric glycopeptides represents a major challenge for mass spectrometry-based characterisation techniques. Here we show that the regiochemistry of the most common N-acetylneuraminic acid linkages of N-glycans can be identified in a site-specific manner from individual glycopeptides using ion mobility-mass spectrometry analysis of diagnostic fragment ions.
ISSN	13597345
Journal	Chemical Communications
Issue Number	23
Volume Number	52
e-ISSN	1364548X
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2016-03-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Glycopeptides Chemistry Mass Spectrometry Methods N-Acetylneuraminic Acid Journal Article Research Support, Non-U.S. Gov't
Content Type	Text
Resource Type	Article
Subject	Ceramics and Composites Chemistry Surfaces, Coatings and Films Materials Chemistry Metals and Alloys Electronic, Optical and Magnetic Materials Catalysis

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