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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Qiu, Ling Gu, Zhi-guo Lin, Jian-guo Bao, Ling-yu Li, Ke Wang, Yu-xia Zhang, Feng-li Ding, Zheng-dong Xi, Sai-fei Liu, Qing-zhu |
| Description | Author Affiliation: Xi SF ( The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China. zhiguogu@jiangnan.edu.cn.); Bao LY ( The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China. zhiguogu@jiangnan.edu.cn.); Lin JG ( Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China.); Liu QZ ( Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China.); Qiu L ( Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China.); Zhang FL ( The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China. zhiguogu@jiangnan.edu.cn.); Wang YX ( The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China. zhiguogu@jiangnan.edu.cn.); Ding ZD ( The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China. zhiguogu@jiangnan.edu.cn.); Li K ( Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China.); Gu ZG ( The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China. zhiguogu@jiangnan.edu.cn.); |
| Abstract | Four pairs of enantiomers of water-stable tetrahedral metal–organic cages $[Ni_{4}L_{6}]^{8+}$ were facilely synthesized. They efficiently stabilized antiparallel G-quadruplex DNA with moderate enantioselectivity, and displayed promising cytotoxicity against the human cancer cell lines HCT116, HepG2 and MCF-7. These results provide a new insight into the rational design of chiral G-quadruplex-based anticancer agents. |
| ISSN | 13597345 |
| Volume Number | 52 |
| Journal | Chemical Communications |
| Issue Number | 67 |
| e-ISSN | 1364548X |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Publisher Date | 2016-08-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Subscribed |
| Subject Keyword | Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ceramics and Composites Chemistry Surfaces, Coatings and Films Materials Chemistry Metals and Alloys Electronic, Optical and Magnetic Materials Catalysis |
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