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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Abstract | OBJECTIVES--To consider the role of platinum and the relative merits of single agent and combination chemotherapy in the treatment of advanced ovarian cancer. DESIGN--Formal quantitative overview using updated individual patient data from all available randomised trials (published and unpublished). SUBJECTS--8139 patients (6408 deaths) included in 45 different trials. RESULTS--No firm conclusions could be reached. Nevertheless, the results suggest that in terms of survival immediate platinum based treatment was better than non-platinum regimens (overall relative risk 0.93; 95% confidence interval 0.83 to 1.05); platinum in combination was better than single agent platinum when used in the same dose (overall relative risk 0.85; 0.72 to 1.00); and cisplatin and carboplatin were equally effective (overall relative risk 1.05; 0.94 to 1.18). CONCLUSIONS--In the past, randomised clinical trials of chemotherapy in advanced ovarian cancer have been much too small to detect the degree of benefit which this overview suggests is realistic for currently available chemotherapeutic regimens. Hence a new trial comparing cisplatin, doxorubicin, and cyclophosphamide (CAP) with carboplatin has been launched and plans to accrue 2000 patients. |
| ISSN | 09598138 |
| e-ISSN | 17561833 |
| Journal | BMJ (British Medical Journal) |
| Issue Number | 6807 |
| Volume Number | 303 |
| Language | English |
| Publisher | British Medical Journal Publishing Group |
| Publisher Date | 1991-12-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Antineoplastic Agents Therapeutic Use Ovarian Neoplasms Drug Therapy Antineoplastic Combined Chemotherapy Protocols Carboplatin Administration & Dosage Cisplatin Infant, Newborn Meta-Analysis As Topic Mortality Platinum Randomized Controlled Trials As Topic Survival Rate Meta-Analysis Medicine |
| Content Type | Text |
| Resource Type | Article |
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