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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | El Ghomari, H. Sabri, M. Belkhadir, J. Klöcker, N. Mikou, A. Nasciri, M. |
| Description | Author Affiliation: Belkhadir J ( Medical Department E, University Hospital Ibn Sina, Rabat, Morocco.); |
| Abstract | OBJECTIVE: To compare the efficacy of two glibenclamide regimens in patients with non-insulin dependent diabetes who were fasting during Ramadan and regular glibenclamide treatment in the non-fasting group. DESIGN: Non-randomised control group of patients who did not fast during Ramadan and two groups of patients who fasted randomised equally to one of two regimens: to take their usual morning dose of glibenclamide in the evening and their usual evening dose before dawn; or to follow this pattern but to reduce the total dose by a quarter. SETTING: Two university hospitals, one private hospital, and two private clinics in Casablanca and Rabat, Morocco. SUBJECTS: 591 diabetic patients (198 men, 391 women, two unspecified) with similar duration of diabetes and length and amount of glibenclamide treatment, of whom 542 completed the study. MAIN OUTCOME MEASURES: Serum fructosamine and total glycated haemoglobin concentrations and number of hypoglycaemic events. RESULTS: At the end of Ramadan there were no significant differences between the groups in fructosamine concentration (400 mumol/l in controls and 381 mumol/l and 376 mumol/l in the fasting groups); percentage of glycated haemoglobin (14.7%, 14.0%, and 13.6%); or number of hypoglycaemic events during Ramadan (11, 14, and 10). CONCLUSION: Glibenclamide is effective and safe for patients with non-insulin dependent diabetes who fast during Ramadan. The easiest regimen is to take the normal morning dose (together with any midday dose) at sunset and any evening dose before dawn. |
| ISSN | 09598138 |
| e-ISSN | 17561833 |
| Journal | BMJ (British Medical Journal) |
| Issue Number | 6899 |
| Volume Number | 307 |
| Language | English |
| Publisher | British Medical Journal Publishing Group |
| Publisher Date | 1993-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Diabetes Mellitus, Type 2 Drug Therapy Fasting Glyburide Therapeutic Use Blood Dose-Response Relationship, Drug Fructosamine Administration & Dosage Hemoglobin A, Glycosylated Hexosamines Hypoglycemia Etiology Clinical Trial Randomized Controlled Trial Medicine |
| Content Type | Text |
| Resource Type | Article |
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