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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Critchley, M. Jenkins, S. A. Grime, J. S. Love, J. G. Kingsnorth, A. N. Makin, C. A. Baxter, J. N. Ellenbogen, S. Sutton, R. |
| Description | Author Affiliation: Jenkins SA ( Department of Surgery, Royal Liverpool University Hospital.); |
| Abstract | OBJECTIVE: To assess the efficacy of long term octreotide as adjuvant treatment to programmed endoscopic sclerotherapy after acute variceal haemorrhage in cirrhotic portal hypertension. DESIGN: Randomised clinical trial. SETTING: University hospital. SUBJECTS: 32 patients with cirrhotic portal hypertension. INTERVENTIONS: Programmed injection sclerotherapy with subcutaneous octreotide 50 micrograms twice daily for 6 months, or programmed injection sclerotherapy alone. MAIN OUTCOME MEASURES: Episodes of recurrent variceal bleeding and survival. RESULTS: Significantly fewer patients receiving combined octreotide and sclerotherapy had episodes of recurrent variceal bleeding compared with patients given sclerotherapy alone (1/16 v 7/16; P = 0.037, Fisher's exact test), and their survival was significantly improved (P < 0.02, log rank test); this improvement was maintained for 12 months after the end of the study. Combined treatment also resulted in a sustained decrease in portal pressure (median decrease -6.0 mm Hg, interquartile range -10 to -4.75 mm Hg, P = 0.0002) compared with sclerotherapy alone (median increase 1.5 mm Hg, interquartile range 0.25 to 3.25 mm Hg), as well as a significant improvement in liver function as assessed by plasma concentrations of bilirubin, albumin, and alanine aminotransferase and by hepatocyte metabolism of aminopyrine labelled with carbon-14. CONCLUSION: Long term octreotide may be a valuable adjuvant to endoscopic sclerotherapy for acute variceal haemorrhage in cirrhotic portal hypertension. |
| ISSN | 09598138 |
| e-ISSN | 17561833 |
| Journal | BMJ (British Medical Journal) |
| Issue Number | 7119 |
| Volume Number | 315 |
| Language | English |
| Publisher | British Medical Journal Publishing Group |
| Publisher Date | 1997-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Gastrointestinal Agents Therapeutic Use Hemorrhage Complications Hypertension, Portal Liver Cirrhosis Drug Therapy Octreotide Varicose Veins Acute Disease Chemotherapy, Adjuvant Adverse Effects Recurrence Sclerotherapy Survival Rate Clinical Trial Randomized Controlled Trial Research Support, Non-U.S. Gov't Medicine |
| Content Type | Text |
| Resource Type | Article |
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