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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Schroeder, Knut Fahey, Tom |
| Description | Author Affiliation: Schroeder K ( Division of Primary Health Care, University of Bristol, Bristol BS6 6JL. k.schroeder@bristol.ac.uk); |
| Abstract | OBJECTIVES: To determine whether over the counter cough medicines are effective for acute cough in adults. DESIGN: Systematic review of randomised controlled trials. DATA SOURCES: Search of the Cochrane Acute Respiratory Infections Group specialised register, Cochrane Controlled Trials Register, Medline, Embase, and the UK Department of Health National Research Register in all languages. INCLUDED STUDIES: All randomised controlled trials that compared oral over the counter cough preparations with placebo in adults with acute cough due to upper respiratory tract infection in ambulatory settings and that had cough symptoms as an outcome. RESULTS: 15 trials involving 2166 participants met all the inclusion criteria. Antihistamines seemed to be no better than placebo. There was conflicting evidence on the effectiveness of antitussives, expectorants, antihistamine-decongestant combinations, and other drug combinations compared with placebo. CONCLUSION: Over the counter cough medicines for acute cough cannot be recommended because there is no good evidence for their effectiveness. Even when trials had significant results, the effect sizes were small and of doubtful clinical relevance. Because of the small number of trials in each category, the results have to be interpreted cautiously. |
| ISSN | 09598138 |
| e-ISSN | 17561833 |
| Journal | BMJ (British Medical Journal) |
| Issue Number | 7333 |
| Volume Number | 324 |
| Language | English |
| Publisher | British Medical Journal Publishing Group |
| Publisher Date | 2002-02-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Antitussive Agents Therapeutic Use Cough Drug Therapy Nonprescription Drugs Acute Disease Adolescent Microbiology Randomized Controlled Trials As Topic Respiratory Tract Infections Complications Research Support, Non-U.S. Gov't Medicine |
| Content Type | Text |
| Resource Type | Article |
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