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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hyppönen, Elina Power, Chris Smith, George Davey |
| Description | Author Affiliation: Hyppönen E ( Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London WC1N 1EH. e.hypponen@ich.ucl.ac.uk); |
| Abstract | Objective To investigate the influences on birth weight of maternal smoking during pregnancy across generations. Design Intergenerational cohort study. Participants Members of the 1958 birth cohort and their offspring and mothers. Setting England, Scotland, and Wales. Main outcome measure Birth weight. Results Information on grandmothers' smoking during pregnancy was available for 9028 singleton offspring of 4302 female cohort members. Assuming heritable transmission through the intergenerational association, grandmothers' smoking was predicted to result in a 34 g reduction (95% confidence interval -41 g to -28 g) in the birth weight of grandchildren. Random effects models showed a negative association between grandmothers' smoking and birth weight of grandchildren (β regression coefficient -24 g, -50 g to 3 g), but this effect was eliminated after adjustment for maternal smoking (0 g, -26 g to 26 g).No association was evident among the offspring of non-smoking mothers (n = 6105; 14 g, -17 g to 46 g), and after adjustment for maternal birth weight, adult height and body mass index, grandmothers' smoking was positively associated with the birth weight of grandchildren (45 g, 10 g to 80 g). Conclusion Deficits in mothers' birth weight attributable to their mother smoking was not evident in the grandchildren. |
| ISSN | 09598138 |
| e-ISSN | 17561833 |
| Journal | BMJ (British Medical Journal) |
| Issue Number | 7420 |
| Volume Number | 327 |
| Language | English |
| Publisher | British Medical Journal Publishing Group |
| Publisher Date | 2003-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Birth Weight Genetics Statistics & Numerical Data Smoking Adverse Effects Cohort Studies Confidence Intervals Gestational Age Infant, Newborn Linear Models Pedigree Pregnancy Prenatal Exposure Delayed Effects Research Support, Non-U.S. Gov't Medicine |
| Content Type | Text |
| Resource Type | Article |
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