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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Harrington, Deborah Duckitt, Kirsten |
| Description | Author Affiliation: Duckitt K ( Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford OX3 9DU. Kduckitt@doctors.org.uk); |
| Abstract | Objective To determine the risk of pre-eclampsia associated with factors that may be present at antenatal booking. Design Systematic review of controlled studies published 1966-2002. Data synthesis Unadjusted relative risks were calculated from published data. Results Controlled cohort studies showed that the risk of pre-eclampsia is increased in women with a previous history of pre-eclampsia (relative risk 7.19, 95% confidence interval 5.85 to 8.83) and in those with antiphospholipids antibodies (9.72, 4.34 to 21.75), pre-existing diabetes (3.56, 2.54 to 4.99), multiple (twin) pregnancy (2.93, 2.04 to 4.21), nulliparity (2.91, 1.28 to 6.61), family history (2.90, 1.70 to 4.93), raised blood pressure (diastolic ≥ 80 mm Hg) at booking (1.38, 1.01 to 1.87), raised body mass index before pregnancy (2.47, 1.66 to 3.67) or at booking (1.55, 1.28 to 1.88), or maternal age ≥ 40 (1.96, 1.34 to 2.87, for multiparous women). Individual studies show that risk is also increased with an interval of 10 years or more since a previous pregnancy, autoimmune disease, renal disease, and chronic hypertension. Conclusions These factors and the underlying evidence base can be used to assess risk at booking so that a suitable surveillance routine to detect pre-eclampsia can be planned for the rest of the pregnancy. |
| ISSN | 09598138 |
| e-ISSN | 17561833 |
| Journal | BMJ (British Medical Journal) |
| Issue Number | 7491 |
| Volume Number | 330 |
| Language | English |
| Publisher | British Medical Journal Publishing Group |
| Publisher Date | 2005-03-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Pre-Eclampsia Etiology Antiphospholipid Syndrome Complications Autoimmune Diseases Birth Intervals Blood Pressure Body Mass Index Epidemiologic Methods Hypertension, Pregnancy-Induced Kidney Diseases Parity Pedigree Physiopathology Pregnancy Pregnancy In Diabetics Pregnancy, Multiple Prenatal Care Medicine |
| Content Type | Text |
| Resource Type | Article |
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