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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gibb, Diana M. Wells, Carole Tudor-williams, Gareth Menson, Esse N. Walker, A. Sarah Sharland, Mike Lyall, E. G. Hermione Riordan, F. Andrew I. |
| Spatial Coverage | Ireland |
| Description | Author Affiliation: Menson EN ( MRC Clinical Trials Unit, London NW1 2DA.); |
| Abstract | Objective To measure the extent of underdosing of antiretroviral drugs in children. Design Multicentre cohort study. Setting Clinical centres in hospitals in the United Kingdom and Ireland in the collaborative HIV paediatric study (CHIPS). Participants 615 HIV infected children aged 2-12 years receiving antiretrovirals. Main outcome measures Doses relative to weight and height compared with current recommended doses in 2004 European guidelines. Results The CHIPS cohort of 934 children comprises 80% of diagnosed HIV infected children in the UK and Ireland between January 1997 and March 2005, of which 66% (615) aged 2-12 years were prescribed antiretrovirals. Actual doses standardised to weight or surface area varied widely across individual drugs, antiretroviral class, and calendar time, with children underdosed (prescribed less than 90% of current recommended doses) from 6-62% child time at risk. Three serious issues in prescribing antiretrovirals, which may also be relevant to paediatric prescribing in general, were identified. Firstly, dosing was inadequate before incorrect recommendations at licensing were later revised when important pharmacokinetic results emerged. Secondly, guidelines stating dosage alternatives (by weight/surface area) for the same drug led to different and inconsistent doses. And, thirdly, ongoing growth was not adjusted for. Conclusions Largely inadvertently, HIV infected children in the United Kingdom and Ireland have been underdosed with antiretrovirals, highlighting problems applicable throughout paediatric prescribing. |
| ISSN | 09598138 |
| e-ISSN | 17561833 |
| Journal | BMJ (British Medical Journal) |
| Issue Number | 7551 |
| Volume Number | 332 |
| Language | English |
| Publisher | British Medical Journal Publishing Group |
| Publisher Date | 2006-05-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Anti-HIV Agents Administration & Dosage Anti-Retroviral Agents HIV Infections Drug Therapy Body Height Body Weight Child, Preschool Cohort Studies Infant Multicenter Study Research Support, Non-U.S. Gov't Medicine |
| Content Type | Text |
| Resource Type | Article |
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