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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Oosterveer, Daniëlla M. Defesche, Joep C. Yazdanpanah, Mojgan Basart, Dick C. G. Lansberg, Peter J. Sijbrands, Eric J. G. Liem, Anho H. Versmissen, Jorie Witteman, Jacqueline C. Heeringa, Jan Kastelein, John J. P. |
| Description | Author Affiliation: Versmissen J ( Department of Internal Medicine, Erasmus University Medical Centre, PO box 2040, 3000 CA Rotterdam, Netherlands.); |
| Abstract | Objective To determine the efficacy of statin treatment on risk of coronary heart disease in patients with familial hypercholesterolaemia. Design Cohort study with a mean follow-up of 8.5 years. Setting 27 outpatient lipid clinics. Subjects 2146 patients with familial hypercholesterolaemia without prevalent coronary heart disease before 1 January 1990. Main outcome measures Risk of coronary heart disease in treated and “untreated” (delay in starting statin treatment) patients compared with a Cox regression model in which statin use was a time dependent variable. Results In January 1990, 413 (21%) of the patients had started statin treatment, and during follow-up another 1294 patients (66%) started after a mean delay of 4.3 years. Most patients received simvastatin (n=1167, 33 mg daily) or atorvastatin (n=211, 49 mg daily). We observed an overall risk reduction of 76% (hazard ratio 0.24 (95% confidence interval 0.18 to 0.30), P<0.001). In fact, the risk of myocardial infarction in these statin treated patients was not significantly greater than that in an age-matched sample from the general population (hazard ration 1.44 (0.80 to 2.60), P=0.23). Conclusion Lower statin doses than those currently advised reduced the risk of coronary heart disease to a greater extent than anticipated in patients with familial hypercholesterolaemia. With statin treatment, such patients no longer have a risk of myocardial infarction significantly different from that of the general population. |
| ISSN | 09598138 |
| e-ISSN | 17561833 |
| Journal | BMJ (British Medical Journal) |
| Volume Number | 337 |
| Language | English |
| Publisher | British Medical Journal Publishing Group |
| Publisher Date | 2008-11-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Heptanoic Acids Administration & Dosage Hydroxymethylglutaryl-CoA Reductase Inhibitors Hyperlipoproteinemia Type II Drug Therapy Myocardial Infarction Prevention & Control Pyrroles Simvastatin Atorvastatin Calcium Cohort Studies Disease-Free Survival Kaplan-Meier Estimate Risk Factors Multicenter Study Research Support, Non-U.S. Gov't Medicine |
| Content Type | Text |
| Resource Type | Article |
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