NDLI: Avaliação da doença de Alzheimer através da espectroscopia de prótons por ressonância magnética: comparação entre os achados no cíngulo posterior e nos hipocampos

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Avaliação da doença de Alzheimer através da espectroscopia de prótons por ressonância magnética: comparação entre os achados no cíngulo posterior e nos hipocampos

Content Provider	World Health Organization (WHO)-Global Index Medicus
Researcher	Lee, Hae Won
Description	Responsible library: BR66.1 Localization: BR66.1, FM-2, L516av; W4.DB8
Abstract	Foi realizada a comparação entre os achados de espectroscopia de prótons por ressonância magnética utilizando a sequência PRESS (point resolved spectroscopy), com TE curto (35ms) no cíngulo posterior e hipocampos de 29 pacientes com doença de Alzheimer (leve e moderada) e 15 controles. As relações de metabólitos com melhor sensibilidade e especificidade na diferenciação entre os grupos foram em ordem decrescente: Naa/Cr do cíngulo, mI/Naa do cíngulo, mI/Naa dos hipocampos e mI/Cr dos hipocampos / The objective of this study is to compare the findings on Magnetic Resonance Spectroscopy using PRESS (point resolved spectroscopy) technique with short TE (35ms) in the posterior cingulate and hippocampi of 29 patients with Alzheimers disease (mild and moderate) and 15 controls. The metabolic ratios with highest sensitivity and specificity were (in a decreasing order): posterior cingulate Naa/Cr, posterior cingulate mI/Naa, hippocampi mI/Naa and hippocampi mI/Cr. In the group analised it seems there is no advantage in performing MRS in the hippocampi instead of posterior cingulate, a technically challenging location, usually leading to a longer examination time. In the posterior cingulate we observed a positive correlation with Naa/Cr ratio and a negative correlation with mI/Naa ratio and the MMSE...
File Format	PDF
Language	Portuguese
Publisher Date	2005-01-01
Publisher Department	Faculdade de Medicina,Departamento de Radiologia
Publisher Institution	Universidade de São Paulo
Publisher Place	São Paulo
Access Restriction	Open
Subject Keyword	Magnetic Resonance Spectroscopy Gyrus Cinguli Alzheimer Disease Hippocampus
Content Type	Text
Educational Degree	Doctor of Philosophy (Ph.D.)
Resource Type	Thesis

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