NDLI: Emerging clinical applications in cardiovascular pharmacogenomics.

Please wait, while we are loading the content...

Emerging clinical applications in cardiovascular pharmacogenomics.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Damani, Samir B. Topol, Eric J.
Description	Country affiliation: United States Author Affiliation: Damani SB ( Division of Cardiovascular Diseases, Scripps Clinic, Scripps Translational Science Institute, La Jolla, CA, USA.)
Abstract	Over one-fourth of the 36 million annual outpatient prescriptions filled in the United States are known to have human genomic biomarker information available that predicts drug safety and efficacy, or both. However, to date, we have not systematically implemented strategies to effectively use this data in clinical practice to improve patient outcomes. Part of the difficulty has stemmed from the only modest predictive capacity of previously identified gene variants, lack of replication of data in multiple studies, and the hesitancy of the clinical community to translate data gleaned from basic and translational research to routine clinical practice. Now, additional key variants that strongly impact drug absorption, metabolism, and excretion are rapidly surfacing through the use of genome-wide association technology. Most importantly, these variants are being validated in independent cohorts of thousands of cases and controls. In the near future, the dramatic reduction in the cost of DNA sequencing will lead to further insight into the common and rare genetic variants that strongly predict our individual response to commonly used medications. The clinical community will need to be prepared to utilize this vital data in aiding their selection of the right drug for the right patient if we expect to significantly reduce the ever increasing burden of societies' most common diseases. Herein, we detail the most clinically compelling and robust examples of pharmacogenomics emerging in the field of cardiovascular disease and hopefully foretell how cardiovascular disease might be treated in the era of genomic medicine.
File Format	HTM / HTML
ISSN	19395094
e-ISSN	1939005X
DOI	10.1002/wsbm.113
Journal	Wiley Interdisciplinary Reviews: Systems Biology and Medicine
Issue Number	2
Volume Number	3
Language	English
Publisher	Wiley
Publisher Date	2011-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Computational Biology Cardiovascular Agents Therapeutic Use Cardiovascular Diseases Drug Therapy Genetics Hematologic Agents Animals Pharmacogenetics Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Cardiovascular pharmacogenomics: the future of cardiovascular therapeutics?

Cardiovascular pharmacogenomics and individualized drug therapy.

Pharmacogenomics in cardiology--genetics and drug response: 10 years of progress.

Therapeutic applications of PARP inhibitors: anticancer therapy and beyond.

Pharmacogenomics of cisplatin sensitivity in non-small cell lung cancer.

The pharmacogenetics research network: from SNP discovery to clinical drug response.

Cancer pharmacogenomics: strategies and challenges.

The role of pharmacogenomics in improving the management of asthma.

Emerging concepts in the pharmacogenomics of arrhythmias: ion channel trafficking.

Emerging clinical applications in cardiovascular pharmacogenomics.

Similar Documents

Cardiovascular pharmacogenomics: the future of cardiovascular therapeutics?

Cardiovascular pharmacogenomics and individualized drug therapy.

Pharmacogenomics in cardiology--genetics and drug response: 10 years of progress.

Therapeutic applications of PARP inhibitors: anticancer therapy and beyond.

Pharmacogenomics of cisplatin sensitivity in non-small cell lung cancer.

The pharmacogenetics research network: from SNP discovery to clinical drug response.

Cancer pharmacogenomics: strategies and challenges.

The role of pharmacogenomics in improving the management of asthma.

Emerging concepts in the pharmacogenomics of arrhythmias: ion channel trafficking.

Emerging clinical applications in cardiovascular pharmacogenomics.