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Microcomputed tomography characterization of neovascularization in bone tissue engineering applications.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Young, Simon Kretlow, James D. Nguyen, Charles Bashoura, Alex G. Baggett, L. Scott Jansen, John A. Wong, Mark Mikos, Antonios G.
Description	Country affiliation: United States Author Affiliation: Young S ( Department of Bioengineering, Rice University, Houston, Texas, USA.)
Abstract	Vasculogenesis and angiogenesis have been studied for decades using numerous in vitro and in vivo systems, fulfilling the need to elucidate the mechanisms involved in these processes and to test potential therapeutic agents that inhibit or promote neovascularization. Bone tissue engineering in particular has benefited from the application of proangiogenic strategies, considering the need for an adequate vascular supply during healing and the challenges associated with the vascularization of scaffolds implanted in vivo. Conventional methods of assessing the in vivo angiogenic response to tissue-engineered constructs tend to rely on a two-dimensional assessment of microvessel density within representative histological sections without elaboration of the true vascular tree. The introduction of microcomputed tomography (micro-CT) has recently allowed investigators to obtain a diverse range of high-resolution, three-dimensional characterization of structures, including renal, coronary, and hepatic vascular networks, as well as bone formation within healing defects. To date, few studies have utilized micro-CT to study the vascular response to an implanted tissue engineering scaffold. In this paper, conventional in vitro and in vivo models for studying angiogenesis will be discussed, followed by recent developments in the use of micro-CT for vessel imaging in bone tissue engineering research. A new study demonstrating the potential of contrast-enhanced micro-CT for the evaluation of in vivo neovascularization in bony defects is described, which offers significant potential in the evaluation of bone tissue engineering constructs.
File Format	HTM / HTML
ISSN	19373368
e-ISSN	19373376
DOI	10.1089/ten.teb.2008.0153
Journal	Tissue Engineering Part B: Reviews
Issue Number	3
Volume Number	14
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2008-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Biotechnology Bone And Bones Blood Supply Neovascularization, Physiologic Physiology Tissue Engineering Tissue Scaffolds Tomography, X-ray Computed Angiogenesis Inhibitors Therapeutic Use Animals Bone Diseases Surgery Neovascularization, Pathologic Drug Therapy Pathology Prosthesis Implantation Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biochemistry Bioengineering Biomedical Engineering

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