NDLI: Tissue engineering and regenerative strategies to replicate biocomplexity of vascular elastic matrix assembly.

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Tissue engineering and regenerative strategies to replicate biocomplexity of vascular elastic matrix assembly.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bashur, Chris A. Venkataraman, Lavanya Ramamurthi, Anand
Description	Country affiliation: United States Author Affiliation: Bashur CA ( Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio, USA.)
Abstract	Cardiovascular tissues exhibit architecturally complex extracellular matrices, of which the elastic matrix forms a major component. The elastic matrix critically maintains native structural configurations of vascular tissues, determines their ability to recoil after stretch, and regulates cell signaling pathways involved in morphogenesis, injury response, and inflammation via biomechanical transduction. The ability to tissue engineer vascular replacements that incorporate elastic matrix superstructures unique to cardiac and vascular tissues is thus important to maintaining vascular homeostasis. However, the vascular elastic matrix is particularly difficult to tissue engineer due to the inherently poor ability of adult vascular cells to synthesize elastin precursors and organize them into mature structures in a manner that replicates the biocomplexity of elastic matrix assembly during development. This review discusses current tissue engineering materials (e.g., growth factors and scaffolds) and methods (e.g., dynamic stretch and contact guidance) used to promote cellular synthesis and assembly of elastic matrix superstructures, and the limitations of these approaches when applied to smooth muscle cells, the primary elastin-generating cell type in vascular tissues. The potential application of these methods for in situ regeneration of disrupted elastic matrix at sites of proteolytic vascular disease (e.g., abdominal aortic aneurysms) is also discussed. Finally, the review describes the potential utility of alternative cell types to elastic tissue engineering and regenerative matrix repair. Future progress in the field is contingent on developing a thorough understanding of developmental elastogenesis and then mimicking the spatiotemporal changes in the cellular microenvironment that occur during that phase. This will enable us to tissue engineer clinically applicable elastic vascular tissue replacements and to develop elastogenic therapies to restore homeostasis in de-elasticized vessels.
File Format	HTM / HTML
ISSN	19373368
e-ISSN	19373376
DOI	10.1089/ten.TEB.2011.0521
Journal	Tissue Engineering Part B: Reviews
Issue Number	3
Volume Number	18
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2012-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Biotechnology Biocompatible Materials Pharmacology Blood Vessels Physiology Elasticity Drug Effects Extracellular Matrix Metabolism Regeneration Tissue Engineering Animals
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biochemistry Bioengineering Biomedical Engineering

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