NDLI: Dynamic manipulation of hydrogels to control cell behavior: a review.

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Dynamic manipulation of hydrogels to control cell behavior: a review.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Vats, Kanika Benoit, Danielle S. W.
Description	Author Affiliation: Vats K ( 1 Department of Biomedical Engineering, University of Rochester , Rochester, New York.)
Abstract	For many tissue engineering applications and studies to understand how materials fundamentally affect cellular functions, it is important to have the ability to synthesize biomaterials that can mimic elements of native cell-extracellular matrix interactions. Hydrogels possess many properties that are desirable for studying cell behavior. For example, hydrogels are biocompatible and can be biochemically and mechanically altered by exploiting the presentation of cell adhesive epitopes or by changing hydrogel crosslinking density. To establish physical and biochemical tunability, hydrogels can be engineered to alter their properties upon interaction with external driving forces such as pH, temperature, electric current, as well as exposure to cytocompatible irradiation. Additionally, hydrogels can be engineered to respond to enzymes secreted by cells, such as matrix metalloproteinases and hyaluronidases. This review details different strategies and mechanisms by which biomaterials, specifically hydrogels, can be manipulated dynamically to affect cell behavior. By employing the appropriate combination of stimuli and hydrogel composition and architecture, cell behavior such as adhesion, migration, proliferation, and differentiation can be controlled in real time. This three-dimensional control in cell behavior can help create programmable cell niches that can be useful for fundamental cell studies and in a variety of tissue engineering applications.
File Format	HTM / HTML
ISSN	19373368
e-ISSN	19373376
DOI	10.1089/ten.TEB.2012.0716
Journal	Tissue Engineering Part B: Reviews
Issue Number	6
Volume Number	19
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2013-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Biotechnology Cells Cytology Drug Effects Hydrogels Chemistry Pharmacology Materials Testing Animals Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biochemistry Bioengineering Biomedical Engineering

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