NDLI: Human Adipose Stem Cells: From Bench to Bedside.

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Human Adipose Stem Cells: From Bench to Bedside.

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Human Adipose Stem Cells: From Bench to Bedside.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	De Francesco, Francesco Ricci, Giulia D'Andrea, Francesco Nicoletti, Giovanni Francesco Ferraro, Giuseppe Andrea
Description	Country affiliation: Italy Author Affiliation: De Francesco F ( 1 Multidisciplinary Department of Medical-Surgical and Dental Specialties, Second University of Naples , Naples, Italy .); Ricci G ( 2 Department of Experimental Medicine, Second University of Naples , Naples, Italy .); D'Andrea F ( 1 Multidisciplinary Department of Medical-Surgical and Dental Specialties, Second University of Naples , Naples, Italy .); Nicoletti GF ( 1 Multidisciplinary Department of Medical-Surgical and Dental Specialties, Second University of Naples , Naples, Italy .); Ferraro GA ( 1 Multidisciplinary Department of Medical-Surgical and Dental Specialties, Second University of Naples , Naples, Italy .)
Abstract	Stem cell-based therapies for repair and regeneration of different tissues are becoming more important in the treatment of several diseases. Adult stem cells currently symbolize the most available source of cell progenitors for tissue engineering and repair and can be harvested using minimally invasive procedures. Moreover, mesenchymal stem cells (MSCs), the most widely used stem cells in stem cell-based therapies, are multipotent progenitors, with capability to differentiate into cartilage, bone, connective, muscle, and adipose tissue. So far, bone marrow has been regarded as the main source of MSCs. To date, human adult adipose tissue may be the best suitable alternative source of MSCs. Adipose stem cells (ASCs) can be largely extracted from subcutaneous human adult adipose tissue. A large number of studies show that adipose tissue contains a biologically and clinically interesting heterogeneous cell population called stromal vascular fraction (SVF). The SVF may be employed directly or cultured for selection and expansion of an adherent population, so called adipose-derived stem cells (ASCs). In recent years, literature based on data related to SVF cells and ASCs has augmented considerably: These studies have demonstrated the efficacy and safety of SVF cells and ASCs in vivo in animal models. On the basis of these observations, in several countries, various clinical trials involving SVF cells and ASCs have been permitted. This review aims at summarizing data regarding either ASCs cellular biology or ASCs-based clinical trials and at discussing the possible future clinical translation of ASCs and their potentiality in cell-based tissue engineering.
File Format	HTM / HTML
ISSN	19373368
e-ISSN	19373376
Journal	Tissue Engineering Part B: Reviews
Issue Number	6
Volume Number	21
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2015-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Biotechnology Adipose Tissue Adult Stem Cells Cell Culture Techniques Cell Differentiation Mesenchymal Stromal Cells Tissue Engineering Cytology Metabolism Animals Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biochemistry Bioengineering Biomedical Engineering

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