NDLI: Molecular characterization of inflammation and Staphylococcus aureus colonization of involved skin of atopic dermatitis patients. A non-invasive approach.

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Molecular characterization of inflammation and Staphylococcus aureus colonization of involved skin of atopic dermatitis patients. A non-invasive approach.

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Molecular characterization of inflammation and Staphylococcus aureus colonization of involved skin of atopic dermatitis patients. A non-invasive approach.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Casas, C. Ginisty, H. Alvarez-Georges, S. Viodé, C. Lejeune, O. Rouvrais, C. Schmitt, A. M. Redoulès, D.
Description	Country affiliation: France Author Affiliation: Casas C ( Institut de Recherche Pierre Fabre, Cerper, Toulouse, France.)
Abstract	Atopic dermatitis (AD) is a multifactorial chronic inflammatory disease mainly stemming from a genetic predisposition that leads to hypersensitivity to environmental factors and a common involvement of Staphylococcus aureus (SA) colonization. The aim of this work was to propose a new non-invasive approach to enumerate the genes coding for the toxins of SA in atopic skin samples. In parallel, the study aimed to evaluate the change in AD through 3 markers of the inflammatory response: IL-8, IL-1RA/IL-1alpha and IL-18. These methods were tested on 31 patients with AD, and finally on a group of 19 subjects for whom clinical improvement had been reported after various treatments. The study revealed the presence of a large number of genes encoding toxins in atopic samples, indicating a high rate of SA colonization, and also an increase in the level of all cytokine markers in atopic skin compared to the skin of healthy subjects. Finally, we found a positive correlation between increases in the SCORAD (Scoring Atopic Dermatitis Index) value after treatment and the corresponding evolution of the SA density. These methods provide a means to clinically evaluate the course of AD, and may help in the development of potential treatments.
File Format	HTM / HTML
ISSN	16605527
e-ISSN	16605535
Journal	Skin Pharmacology and Physiology
Issue Number	5
Volume Number	21
Language	English
Publisher	Karger
Publisher Date	2008-01-01
Publisher Place	Switzerland
Access Restriction	Open
Subject Keyword	Discipline Physiology Discipline Pharmacology Discipline Dermatology Bacterial Toxins Genetics Dermatitis, Atopic Polymerase Chain Reaction Staphylococcus Aureus Isolation & Purification Case-control Studies Child, Preschool Dna, Bacterial Microbiology Genetic Predisposition To Disease Genotype Infant Inflammation Interleukins Metabolism Oligonucleotide Array Sequence Analysis Severity Of Illness Index Staphylococcal Skin Infections
Content Type	Text
Resource Type	Article
Subject	Physiology Pharmacology Dermatology

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