NDLI: Evaluation of a Self-Test Device Used in Allergic Contact Dermatitis.

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Evaluation of a Self-Test Device Used in Allergic Contact Dermatitis.

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Evaluation of a Self-Test Device Used in Allergic Contact Dermatitis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Elsner, Peter Bjarnøe, Henriette Aberer, Werner Brasch, Jochen
Description	Country affiliation: Germany Author Affiliation: Elsner P ( Department of Dermatology, University Hospital Jena, Jena, Germany.)
Abstract	Considering the scarcity of dermatologic resources in many parts of the world, self-testing by patients is not only of interest for internal medicine but also for dermatology. In this open, nonrandomized, multicenter diagnostic trial involving subjects with suspected contact sensitization to nickel and/or a fragrance mix, we assessed the agreement of self-testing by subjects with readings made by dermatologists. The self-test product (Nixema(TM)) is based on Thin-Layer Rapid Use Epicutaneous Test (TRUE Test®) technology. One hundred and sixty-five subjects self-tested the ready-made patch-test product. The test was applied for 48 h and then read after 3 or 4 days. It was also evaluated independently by experienced dermatologists after 3 or 4 days. In the 162 evaluable subjects, the proportion of agreement for both allergens together was 89.5% [95% confidence interval (CI) 83.7-93.8], the sensitivity was 97.5 % (95% CI 86.8-99.9) and the specificity was 86.9% (95% CI 79.6-92.3). Cohen's kappa was also high at 0.749 (95% CI 0.637-0.862). Discrepancies between the subjects' readings and the dermatologists' readings were mainly due to the subjects interpreting reactions of 'irritant' or 'doubtful' as 'positive'. Apart from itching and burning sensations and tape irritation, no side effects were observed. In conclusion, this study showed a high rate of agreement between the self-reading of the upper arm and the readings made by the dermatologists. The upper arm proved to be an appropriate area for self-testing. Self-testing may improve the screening for contact sensitization for patients, particularly where dermatologic health resources are scarce.
File Format	HTM / HTML
ISSN	16605527
e-ISSN	16605535
Journal	Skin Pharmacology and Physiology
Issue Number	5
Volume Number	28
Language	English
Publisher	Karger
Publisher Date	2015-01-01
Publisher Place	Switzerland
Access Restriction	Open
Subject Keyword	Discipline Physiology Discipline Pharmacology Discipline Dermatology Allergens Immunology Dermatitis, Allergic Contact Diagnosis Patch Tests Nickel Adverse Effects Perfume Sensitivity And Specificity Time Factors Clinical Trial, Phase Iv Multicenter Study
Content Type	Text
Resource Type	Article
Subject	Physiology Pharmacology Dermatology

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