NDLI: MicroRNAs and benign biliary tract diseases.

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MicroRNAs and benign biliary tract diseases.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gradilone, Sergio A. O'Hara, Steven P. Masyuk, Tetyana V. Pisarello, Maria Jose Lorenzo LaRusso, Nicholas F.
Description	Author Affiliation: Gradilone SA ( Division of Gastroenterology and Hepatology, and the Mayo Clinic Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, Minnesota.); O'Hara SP ( Division of Gastroenterology and Hepatology, and the Mayo Clinic Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, Minnesota.); Masyuk TV ( Division of Gastroenterology and Hepatology, and the Mayo Clinic Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, Minnesota.); Pisarello MJ ( Division of Gastroenterology and Hepatology, and the Mayo Clinic Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, Minnesota.); LaRusso NF ( Division of Gastroenterology and Hepatology, and the Mayo Clinic Center for Cell Signaling in Gastroenterology, Mayo Clinic, Rochester, Minnesota.)
Abstract	Cholangiocytes, the epithelial cells lining the biliary tree, represent only a small portion of the total liver cell population (3-5%), but they are responsible for the secretion of up to 40% of total daily bile volume. In addition, cholangiocytes are the target of a diverse group of liver diseases affecting the biliary tract, the cholangiopathies; for most of these conditions, the pathological mechanisms are unclear. MicroRNAs (miRNAs) are small, noncoding RNAs that posttranscriptionally regulate gene expression. Thus, it is not surprising that altered miRNA profiles underlie the dysregulation of several proteins involved in the pathobiology of the cholangiopathies, as well as showing promise as diagnostic and prognostic tools. Here the authors review recent work relevant to the role of miRNAs in the etiopathogenesis of several of the cholangiopathies (i.e., fibroinflammatory cholangiopathies and polycystic liver diseases), discuss their value as prognostic and diagnostic tools, and provide suggestions for further research.
File Format	HTM / HTML
ISSN	02728087
e-ISSN	10988971
DOI	10.1055/s-0034-1397346
Journal	Seminars in Liver Disease
Issue Number	1
Volume Number	35
Language	English
Publisher	Thieme
Publisher Date	2015-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Gastroenterology Biliary Tract Diseases Genetics Epithelial Cells Metabolism Micrornas Bile Duct Neoplasms Bile Ducts, Intrahepatic Biliary Atresia Biliary Tract Cytology Cholangiocarcinoma Cholangitis, Sclerosing Liver Cirrhosis, Biliary Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Hepatology

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