NDLI: The role of targeted molecular inhibitors in the management of advanced nonmelanoma skin cancer.

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The role of targeted molecular inhibitors in the management of advanced nonmelanoma skin cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	O'Bryan, Kevin W. Ratner, Desiree
Description	Country affiliation: United States Author Affiliation: O'Bryan KW ( Columbia University Department of Dermatology, Division of Dermatologic Surgery, New York, NY 10032, USA. kobryan1@gmail.com)
Abstract	Surgical treatment remains the standard of care for nonmelanoma skin cancer and is successful for the vast majority of patients with these tumors. The treatment of patients with metastatic or unresectable nonmelanoma skin cancer, however, has until recently been based solely on traditional methods of chemotherapy and radiation. However, these methods have high rates of treatment failure, morbidity, and mortality, and alternative treatment modalities for patients with aggressive or advanced disease are needed. As in other areas of cancer therapeutics, recent research elucidating the molecular basis of cancer development, and the subsequent arrival of targeted molecular inhibitors for cancer therapy, have been met with much excitement. In this review, we seek to illuminate recent developments and future possibilities in the use of targeted molecular inhibitors for treatment of advanced squamous cell carcinoma, basal cell carcinoma, and dermatofibrosarcoma protuberans.
File Format	HTM / HTML
ISSN	10855629
Issue Number	1
Volume Number	30
e-ISSN	15580768
Journal	Seminars in Cutaneous Medicine and Surgery
Language	English
Publisher	Frontline Medical Communications
Publisher Date	2011-03-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline General Surgery Discipline Dermatology Carcinoma, Basal Cell Drug Therapy Carcinoma, Squamous Cell Carcinoma Dermatofibrosarcoma Head And Neck Neoplasms Molecular Targeted Therapy Neoplasms, Squamous Cell Skin Neoplasms Anilides Therapeutic Use Antineoplastic Agents Benzamides Humans Imatinib Mesylate Piperazines Pyridines Pyrimidines Receptor, Epidermal Growth Factor Antagonists & Inhibitors Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Surgery Dermatology

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