NDLI: Acetate but not propionate induces oxidative stress in bakers' yeast Saccharomyces cerevisiae.

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Acetate but not propionate induces oxidative stress in bakers' yeast Saccharomyces cerevisiae.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Semchyshyn, Halyna M. Abrat, Oleksandra B. Miedzobrodzki, Jacek Inoue, Yoshiharu Lushchak, Volodymyr I.
Description	Country affiliation: Ukraine Author Affiliation: Semchyshyn HM ( Department of Biochemistry and Biotechnology, Vassyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine. semchyshyn@pu.if.ua)
Abstract	The influence of acetic and propionic acids on baker's yeast was investigated in order to expand our understanding of the effect of weak organic acid food preservatives on eukaryotic cells. Both acids decreased yeast survival in a concentration-dependent manner, but with different efficiencies. The acids inhibited the fluorescein efflux from yeast cells. The inhibition constant of fluorescein extrusion from cells treated with acetate was significantly lower in parental strain than in either PDR12 (ABC-transporter Pdr12p) or WAR1 (transcriptional factor of Pdr12p) defective mutants. The constants of inhibition by propionate were virtually the same in all strains used. Yeast exposure to acetate increased the level of oxidized proteins and the activity of antioxidant enzymes, while propionate did not change these parameters. This suggests that various mechanisms underlie the yeast toxicity by acetic and propionic acids. Our studies with mutant cells clearly indicated the involvement of Yap1p transcriptional regulator and de novo protein synthesis in superoxide dismutase up-regulation by acetate. The up-regulation of catalase was Yap1p independent. Yeast pre-incubation with low concentrations of H2O2 caused cellular cross-protection against high concentrations of acetate. The results are discussed from the point of view that acetate induces a prooxidant effect in vivo, whereas propionate does not.
File Format	HTM / HTML
ISSN	13510002
e-ISSN	17432928
Journal	Redox Report
Issue Number	1
Volume Number	16
Language	English
Publisher	Taylor & Francis
Publisher Date	2011-01-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Metabolism Discipline Biochemistry Acetic Acid Pharmacology Oxidative Stress Propionates Saccharomyces Cerevisiae Drug Effects Atp-binding Cassette Transporters Genetics Catalase Metabolism Fluorescein Pharmacokinetics Food Preservatives Gene Expression Regulation, Fungal Hydrogen Peroxide Mutation Protein Carbonylation Enzymology Growth & Development Saccharomyces Cerevisiae Proteins Superoxide Dismutase Transcription Factors Up-regulation Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Cell Biology Physiology Biochemistry Clinical Biochemistry

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