NDLI: Senile onset frontotemporal lobar degeneration with TAR-DNA binding protein 43 proteinopathy primarily presenting with wasteful habits.

Please wait, while we are loading the content...

Year: 2016 Volume: 16

Year: 2015 Volume: 15

Year: 2014 Volume: 14

Year: 2013 Volume: 13

Year: 2013 Volume: 13 Issue: 4

Vision, quality of life and depressive symptoms after first eye cataract surgery.

Three patients with mood disorders showing catatonia and frontotemporal lobes atrophy.

Clinical utility of the functional independence measure for assessment of patients with Alzheimer's disease and vascular dementia.

Daytime sleepiness: a risk factor for poor social engagement among the elderly.

Stressful life events and neuroticism as predictors of late-life versus early-life depression.

Mental illness and a high-risk, elderly Japanese population: characteristic differences related to gender and residential location.

Clinical features of late-onset schizophrenia in Japan: comparison with early-onset cases.

Levodopa treatment and mood fluctuation in dementia with Lewy bodies: a case report.

Senile onset frontotemporal lobar degeneration with TAR-DNA binding protein 43 proteinopathy primarily presenting with wasteful habits.

Year: 2013 Volume: 13 Issue: 3

Year: 2013 Volume: 13 Issue: 2

Year: 2013 Volume: 13 Issue: 1

Year: 2012 Volume: 12

Year: 2011 Volume: 11

Year: 2010 Volume: 10

Year: 2009 Volume: 9

Senile onset frontotemporal lobar degeneration with TAR-DNA binding protein 43 proteinopathy primarily presenting with wasteful habits.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Iwasaki, Yasushi Mori, Keiko Ito, Masumi Tatsumi, Shinsui Mimuro, Maya Yoshida, Mari
Description	Author Affiliation: Iwasaki Y ( Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Nagakute.)
Abstract	We present an autopsied case of a senile Japanese woman with sporadic frontotemporal lobar degeneration (FTLD) presenting as frontotemporal dementia. Disease onset was at the age of 70 and presented as a behaviour disorder, particularly involving wasteful habits. The patient had repeated incidents of making expensive purchases and then had difficulty making payments. Following these symptoms, she showed other changes of character such as lethargy and apathy. She gradually showed signs of parkinsonism including rigidity and bradykinesia, and in the terminal stage, an akinetic mutism state with quadriplegia in flexion was observed. Head magnetic resonance imaging revealed severe frontotemporal lobe atrophy with severe lateral ventricular dilatation and frontal white matter degeneration. At autopsy, the brain weighed 930 g and the frontotemporal cerebral cortex showed neuron loss with gliosis, tissue rarefaction and spongiform change, particularly in the superficial layers. Pathologic degeneration was more severe in the anterior portion of the frontal lobe with extensive white matter degeneration. Immunostaining for phosphorylated TAR-DNA binding protein 43 (TDP-43) revealed numerous neuronal cytoplasmic inclusions and extensive short dystrophic neuritis, particularly in the frontotemporal cortex. Many TDP-43-positive cytoplasmic inclusions were also observed in the dentate gyrus of the hippocampus. The patient was pathologically diagnosed with FTLD with TDP-43-positive inclusions (FTLD-TDP) without motor neuron disease. The immunohistochemical findings corresponded to type A of the FTLD-TDP pathology classification system.
File Format	HTM / HTML
ISSN	13463500
Issue Number	4
Volume Number	13
e-ISSN	14798301
Journal	Psychogeriatrics
Language	English
Publisher	Wiley
Publisher Date	2013-12-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Geriatrics Discipline Psychology Dna-binding Proteins Frontotemporal Dementia Complications Frontotemporal Lobar Degeneration Habits Mental Disorders Aged Atrophy Autopsy Female Frontal Lobe Pathology Diagnosis Humans Magnetic Resonance Imaging Methods Temporal Lobe Case Reports Journal Article
Content Type	Text
Resource Type	Case study Article
Subject	Gerontology Geriatrics and Gerontology Psychiatry and Mental Health

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in