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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Nikkhoo, Mohammad Hsu, Yu-Chun Haghpanahi, Mohammad Parnianpour, Mohamad Wang, Jaw-Lin |
| Description | Country affiliation: Iran Author Affiliation: Nikkhoo M ( School of Mechanical Engineering, Iran University of Science and Technology, Tehran, Iran.) |
| Abstract | Finite element analysis is an effective tool to evaluate the material properties of living tissue. For an interactive optimization procedure, the finite element analysis usually needs many simulations to reach a reasonable solution. The meta-model analysis of finite element simulation can be used to reduce the computation of a structure with complex geometry or a material with composite constitutive equations. The intervertebral disc is a complex, heterogeneous, and hydrated porous structure. A poroelastic finite element model can be used to observe the fluid transferring, pressure deviation, and other properties within the disc. Defining reasonable poroelastic material properties of the anulus fibrosus and nucleus pulposus is critical for the quality of the simulation. We developed a material property updating protocol, which is basically a fitting algorithm consisted of finite element simulations and a quadratic response surface regression. This protocol was used to find the material properties, such as the hydraulic permeability, elastic modulus, and Poisson's ratio, of intact and degenerated porcine discs. The results showed that the in vitro disc experimental deformations were well fitted with limited finite element simulations and a quadratic response surface regression. The comparison of material properties of intact and degenerated discs showed that the hydraulic permeability significantly decreased but Poisson's ratio significantly increased for the degenerated discs. This study shows that the developed protocol is efficient and effective in defining material properties of a complex structure such as the intervertebral disc. |
| File Format | HTM / HTML |
| ISSN | 09544119 |
| e-ISSN | 20413033 |
| Journal | Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine |
| Issue Number | 6 |
| Volume Number | 227 |
| Language | English |
| Publisher | Sage Publications |
| Publisher Date | 2013-06-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Biomedical Engineering Body Fluids Metabolism Intervertebral Disc Degeneration Physiopathology Intervertebral Disc Models, Biological Weight-bearing Animals Compressive Strength Computer Simulation Elastic Modulus Finite Element Analysis In Vitro Techniques Permeability Porosity Stress, Mechanical Swine Tensile Strength Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Mechanical Engineering |
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