NDLI: Delayed response task performance as a function of age in cynomolgus monkeys (Macaca fascicularis).

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Darusman, H. S. Call, J. Sajuthi, D. Schapiro, S. J. Gjedde, A. Kalliokoski, O. Hau, J.
Description	Country affiliation: Denmark Author Affiliation: Darusman HS ( Department of Experimental Medicine, University of Copenhagen and National University Hospital, Copenhagen, Denmark.); Call J ( Department of Anatomy, Physiology and Pharmacology, Faculty of Veterinary Medicine, IPB, Bogor, Indonesia.); Sajuthi D ( Max Planck Institute of Evolutionary Anthropology, Leipzig, Germany.); Schapiro SJ ( Primate Research Center, Bogor Agricultural University (IPB), Bogor, Indonesia.); Gjedde A ( Department of Experimental Medicine, University of Copenhagen and National University Hospital, Copenhagen, Denmark.); Kalliokoski O ( Department of Veterinary Sciences, Michael E. Keeling Center for Comparative Medicine and Research, UT MD Anderson Cancer Center, Bastrop, TX, USA.); Hau J ( Department of Neuroscience and Pharmacology, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.)
Abstract	We compared delayed response task performance in young, middle-aged, and old cynomolgus monkeys using three memory tests that have been used with non-human primates. Eighteen cynomolgus monkeys--6 young (4-9 years), 6 middle-aged (10-19 years), and 6 old (above 20 years)--were tested. In general, the old monkeys scored significantly worse than did the animals in the two other age groups. Longer delays between stimulus presentation and response increased the performance differences between the old and younger monkeys. The old monkeys in particular showed signs of impaired visuo-spatial memory and deteriorated memory consolidation and executive functioning. These results add to the body of evidence supporting the utility of Macaca fascicularis in studies of cognition and as a potential translational model for age-associated memory impairment/dementia-related disorders.
File Format	HTM / HTML
ISSN	00328332
e-ISSN	16107365
DOI	10.1007/s10329-013-0397-8
Journal	Primates
Issue Number	2
Volume Number	55
Language	English
Publisher	Springer
Publisher Date	2014-04-01
Publisher Place	Japan
Access Restriction	Open
Subject Keyword	Discipline Zoology Aging Cognition Physiology Macaca Fascicularis Task Performance And Analysis Animals Time Factors Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Animal Science and Zoology

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