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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pahua-Ramos, María Elena Garduño-Siciliano, Leticia Dorantes-Alvarez, Lidia Chamorro-Cevallos, German Herrera-Martínez, Julieta Osorio-Esquivel, Obed Ortiz-Moreno, Alicia |
| Description | Author Affiliation: Pahua-Ramos ME ( Departamento de Ingeniería Bioquímica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Carpio y Plan de Ayala s/n Col. Casco de Santo Tomás, México, D.F, 11340, México.) |
| Abstract | The objective of this study was to evaluate the effect of reduced-calorie avocado paste on lipid serum profile, insulin sensitivity, and hepatic steatosis in rats fed a hypercholesterolemic-high fructose diet. Thirty five male Wistar rats were randomly separated in five groups: Control group (ground commercial diet); hypercholesterolemic diet plus 60 % fructose solution (HHF group); hypercholesterolemic diet plus 60 % fructose solution supplemented with avocado pulp (HHF+A group); hypercholesterolemic diet plus 60 % fructose solution supplemented with reduced-calorie avocado paste (HHF+P group); and hypercholesterolemic diet plus 60 % fructose solution supplemented with a reduced-calorie avocado paste plus fiber (HHF+FP group). The A, P, and FP were supplemented at 2 g/kg/d. The study was carried out for seven weeks. Rats belonging to the HHF group exhibited significantly (P ≤ 0.05) higher total cholesterol, triglycerides, and insulin levels in serum as well as lower insulin sensitivity than the control group. Supplementation with reduced-calorie avocado paste showed a significant (P ≤ 0.05) decrease in total cholesterol (43.1 %), low-density lipoprotein (45.4 %), and triglycerides (32.8 %) in plasma as well as elevated insulin sensitivity compared to the HHF group. Additionally, the liver enzymes alanine aminotransferase and aspartate aminotransferase decreased significantly in the HHF-P group (39.8 and 35.1 %, respectively). These results are likely due to biocompounds present in the reduced-calorie avocado paste, such as polyphenols, carotenoids, chlorophylls, and dietary fibre, which are capable of reducing oxidative stress. Therefore, reduced-calorie avocado paste attenuates the effects of a hypercholesterolemic-high fructose diet in rats. |
| File Format | HTM / HTML |
| ISSN | 09219668 |
| Issue Number | 1 |
| Volume Number | 69 |
| e-ISSN | 15739104 |
| Journal | Plant Foods for Human Nutrition |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2014-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Botany Discipline Nutritional Sciences Cholesterol, Dietary Metabolism Fatty Liver Fructose Insulin Resistance Insulin Blood Lipids Persea Chemistry Alanine Transaminase Animals Antioxidants Pharmacology Therapeutic Use Aspartate Aminotransferases Administration & Dosage Adverse Effects Diet Dietary Carbohydrates Dietary Supplements Etiology Prevention & Control Fruit Liver Drug Effects Enzymology Male Oxidative Stress Plant Extracts Rats Rats, Wistar Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Food Science |
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