NDLI: The role of Rhipicephalus sanguineus sensu lato saliva in the dissemination of Rickettsia conorii in C3H/HeJ mice.

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The role of Rhipicephalus sanguineus sensu lato saliva in the dissemination of Rickettsia conorii in C3H/HeJ mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Milhano, N. Saito, T. B. Bechelli, J. Fang, R. Vilhena, M. DE Sousa, R. Walker, D. H.
Description	Country affiliation: Portugal Author Affiliation: Milhano N ( Centre for the Study of Vectors and Infectious Diseases Dr Francisco Cambournac, National Institute of Health Dr Ricardo Jorge, Águas de Moura, Portugal.); Saito TB ( Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX, U.S.A.); Bechelli J ( Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX, U.S.A.); Fang R ( Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX, U.S.A.); Vilhena M ( Department of Veterinary Medicine, University of Évora, Évora, Portugal.); DE Sousa R ( Centre for the Study of Vectors and Infectious Diseases Dr Francisco Cambournac, National Institute of Health Dr Ricardo Jorge, Águas de Moura, Portugal.); Walker DH ( Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX, U.S.A.)
Abstract	Animal models have been developed for the study of rickettsial pathogenesis. However, to understand what occurs during the natural route of rickettsial transmission via the tick bite, the role of tick saliva should be considered in these models. To address this, we analysed the role of tick saliva in the transmission of Rickettsia conorii (Rickettsiales: Rickettsiaceae) in a murine host by intradermally (i.d.) inoculating two groups of susceptible C3H/HeJ mice with this Rickettsia, and infesting one group with nymphal Rhipicephalus sanguineus sensu lato (Ixodida: Ixodidae) ticks. Quantification of bacterial loads and mRNA levels of interleukin-1ß (IL-1ß), IL-10 and NF-κB was performed in C3H/HeJ lung samples by real-time quantitative polymerase chain reaction (PCR) and real-time reverse transcriptase PCR, respectively. Lung histology was examined to evaluate the pathological manifestations of infection. No statistically significant difference in bacterial load in the lungs of mice was observed between these two groups; however, a statistically significant difference was observed in levels of IL-1ß and NF-κB, both of which were higher in the group inoculated with rickettsiae but not infected with ticks. Lung histology in both groups of animals revealed infiltration of inflammatory cells. Overall, this study showed that i.d. inoculation of R. conorii caused infection in the lungs of C3H/HeJ mice and tick saliva inhibited proinflammatory effects.
File Format	HTM / HTML
ISSN	0269283X
Issue Number	3
Volume Number	29
e-ISSN	13652915
Journal	Medical and Veterinary Entomology
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2015-09-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Veterinary Medicine Discipline Zoology Boutonneuse Fever Transmission Rhipicephalus Sanguineus Physiology Rickettsia Conorii Saliva Microbiology Animals Mice Mice, Inbred C3h Nymph Growth & Development Journal Article
Content Type	Text
Resource Type	Article
Subject	Veterinary Parasitology Ecology, Evolution, Behavior and Systematics Insect Science

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