NDLI: Sustained upregulation of sodium taurocholate cotransporting polypeptide and bile salt export pump and downregulation of cholesterol 7 -hydroxylase in the liver of patients with end-stage primary biliary cirrhosis.

Please wait, while we are loading the content...

Year: 2016 Volume: 49

Year: 2015 Volume: 48

Year: 2014 Volume: 47

Year: 2013 Volume: 46

Year: 2012 Volume: 45

Year: 2011 Volume: 44

Year: 2010 Volume: 43

Year: 2010 Volume: 43 Issue: 4

Year: 2010 Volume: 43 Issue: 3

Role of platelets in placentation.

Sustained upregulation of sodium taurocholate cotransporting polypeptide and bile salt export pump and downregulation of cholesterol 7 -hydroxylase in the liver of patients with end-stage primary biliary cirrhosis.

Basic study of retinal stem/progenitor cell separation from mouse iris tissue.

Novel cis-active structures in the coding region mediate CRM1-dependent nuclear export of IFN- 1 mRNA.

Detection of characteristic distributions of phospholipid head groups and fatty acids on neurite surface by time-of-flight secondary ion mass spectrometry.

Immunohistochemical application of D2-40 as basal cell marker in evaluating atypical small acinar proliferation of initial routine prostatic needle biopsy materials.

Lymphoepithelioma-like carcinoma of the stomach associated with adenosquamous carcinoma.

A duodenal follicular lymphoma associated with the lesion mimicking MALT lymphoma in terminal ileum and Bauhin valve.

Low-grade salivary duct carcinoma of the parotid gland: report of a case with immunohistochemical analysis.

A successfully treated inflammatory myofibroblastic tumor of the mandible with long-term follow-up and review of the literature.

Year: 2010 Volume: 43 Issue: 2

Year: 2010 Volume: 43 Issue: 1

Year: 2009 Volume: 42

Year: 2008 Volume: 41

Sustained upregulation of sodium taurocholate cotransporting polypeptide and bile salt export pump and downregulation of cholesterol 7 -hydroxylase in the liver of patients with end-stage primary biliary cirrhosis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Takeyama, Yasuaki Kanegae, Kazuko Inomata, Shinjiro Takata, Kazuhide Tanaka, Takashi Ueda, Shu-Ichi Yokoyama, Keiji Morihara, Daisuke Nishizawa, Shinya Anan, Akira Irie, Makoto Iwata, Kaoru Shakado, Satoshi Sohda, Tetsuro Sakisaka, Shotaro
Description	Country affiliation: Japan Author Affiliation: Takeyama Y ( Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. yaz@fukuoka-u.ac.jp)
Abstract	To examine the mRNA expression of hepatobiliary transporters in primary biliary cirrhosis (PBC) patients and to compare bile acid absorption, synthesis, and efflux in patients with non-end-stage and end-stage PBC, we obtained liver samples from PBC patients by percutaneous needle biopsy. End-stage PBC was defined as follows: histological stage IV; cirrhosis; serum total bilirubin, ≥4.0 mg/dl; and Child-Pugh Class C. The mRNA expression levels of sodium taurocholate cotransporting polypeptide (NTCP), bile salt export pump (BSEP), and hepatic cholesterol 7 -hydroxylase (CYP7A1) were significantly higher in the PBC patients than in the controls (P < 0.01). The mRNA levels of NTCP and BSEP were significantly higher in the end-stage PBC patients than in the controls (P < 0.01). However, hepatic CYP7A1 mRNA expression decreased significantly (by 70%) in the patients with end-stage PBC as compared to the controls and the patients with non-end-stage PBC (P < 0.01). The hepatic expression of transporters mediating bile acid influx and efflux showed sustained elevation, whereas that of the rate-limiting enzyme for bile acid biosynthesis was attenuated in the end-stage PBC patients. Thus, mechanisms may be present preventing the accumulation of toxic bile acids in the hepatocytes of end-stage PBC patients.
File Format	HTM / HTML
ISSN	18601480
Issue Number	3
Volume Number	43
e-ISSN	18601499
Journal	Medical Molecular Morphology
Language	English
Publisher	Springer
Publisher Date	2010-09-01
Publisher Place	Japan
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Cell Biology Discipline Molecular Biology Discipline Pathology Atp-binding Cassette Transporters Biosynthesis Cholesterol 7-alpha-hydroxylase End Stage Liver Disease Metabolism Liver Cirrhosis, Biliary Liver Organic Anion Transporters, Sodium-dependent Symporters Genetics Bile Acids And Salts Down-regulation Humans Rna, Messenger Up-regulation Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Pathology and Forensic Medicine

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in